• 1
    Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and wales. Lancet 1986; 8489:107781.
  • 2
    Baker CJ, Melish ME, Hall RT, Casto DT, Vasan U, Givner LB. Interavenous immune globulin for the prevention of nosocomial infection in low-birth-weight neonates. The multicenter group for the study of immune globulin in neonates. N Engl J Med 1992; 327:21319.
  • 3
    Smith S, Jacobs RF, Wilson CB. Immunobiology of childhood tuberculosis: a window on the ontogeny of cellular immunity. J Pediatr 1997; 131:1626.
  • 4
    Serushago B, Macdonald C, Lee SH, Stadnyk A, Bortoiussi R. Interferon-gamma detection in cultures of newborn cells exposed to Listeria monocytogenes. J Interferon Cytokine Res 1995; 15:6335.
  • 5
    Shore SL, Milgrom H, Wood PA, Nahmias AJ. Antibody-dependent celluar toxicity to target cells infected with herpes simplex viruses: functional adequacy in the neonate. Pediatrics 1977; 59:228.
  • 6
    Wilson CB. Immunologic basis for increased susceptibility of the neonate to infection. J Pediatr 1986; 108:112.
  • 7
    Hill HR. Biochemical, structural, and functional abnormalities of polymorphonuclear leukocytes in the neonate. Pediatr Res 1987; 22:37582.
  • 8
    Black MM, Fukuyama K, Epstein WL. The induction of human multinucleated monocytes in culture. J Invest Dermatol 1976; 66:902.
  • 9
    Helming L, Gordon S. Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur J Immunol 2007; 37:3342.
  • 10
    Ikeda T, Ikeda K, Sasaki K et al. IL-13 as well as IL-4 induces monocytes/macrophages and a monoblastic cell line (UG3) to differentiate into multinucleated giant cells in the presence of M-CSF. Biochem Biophys Res Commun 1998; 253:26572.
  • 11
    Lemaire HY, Lauzon W, Gendron N. M-CSF and GM-CSF promote alveolar macrophage differentiation into multinucleated giant cells with distinct phenotypes. J Leukoc Biol 1995; 60:50918.
  • 12
    Enelow RI, Sullivan GW, Carper HT, Mandell GL. Induction of multinucleated giant cell formation from in vitro culture of human monocytes with interleukin-3 and interferon-gamma: comparison with other stimulating factors. Am J Respir Cell Mol Biol 1992; 6:5762.
  • 13
    McNally AK, Anderson JM. Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. Am J Pathol 1995; 147:148799.
  • 14
    Maclauchlan S, Skokos EA, Meznarich N et al. Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9. J Leukoc Biol 2009; 85:61726.
  • 15
    McNally AK, Anderson JM. Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol 2002; 160:62130.
  • 16
    Han X, Sterling H, Chen Y et al. CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation. J Biol Chem 2000; 275:3798492.
  • 17
    Chiozzi P, Sanz JM, Ferrari D et al. Spontaneous cell fusion in macrophage cultures expressing high levels of the P2Z/P2X7 receptor. J Cell Biol 1997; 138:697706.
  • 18
    Fais S, Burgio VL, Silvestri M, Capobianchi MR, Pacchiarotti A, Pallone F. Multinucleated giant cells generation induced by interferon-gamma. Changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophages fusion and multinucleated giant cell formation. Lab Invest 1994; 71:73744.
  • 19
    Yagi M, Miyamoto T, Toyama Y, Suda T. Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J Bone Miner Metab 2006; 24:3558.
  • 20
    Kyriakides TR, Foster MJ, Keeney GE et al. The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol 2004; 165:215766.
  • 21
    Namba K, Nishio M, Mori K et al. Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes. Cell Immunol 2001; 213:10413.
  • 22
    Ohgimoto S, Tabata N, Suga S et al. Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules. J Immunol 1995; 155:358592.
  • 23
    McNally AK, Macewan SR, Anderson JM. Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. Exp Mol Pathol 2008; 84:3745.
  • 24
    Orentas RJ, Reinlib L, Hildreth JE. Anti-class II MHC antibody induces multinucleated giant cell formation from peripheral blood monocytes. J Leukoc Biol 1992; 51:199209.
  • 25
    Tabata N, Ito M, Shimokata K et al. Expression of fusion regulatory proteins (FRPs) on human peripheral blood monocytes. Induction of homotypic cell aggregation and formation of multinucleated giant cells by anti-FRP-1 monoclonal antibodies. J Immunol 1994; 153:325666.
  • 26
    McNally AK, DeFife KM, Anderson JM. Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity. Am J Pathol 1996; 149:97585.
  • 27
    Steinberg TH, Hiken JF. P2 receptors in macrophage fusion and osteoclast formation. Purinergic Signal 2007; 3:537.
  • 28
    Zur Hausen H, De Villers EM. Syncytium formation in aged umbilical cord blood macrophage. Attempts to demonstrate an infectious etiology. Med Microbiol Immunol 1982; 170:22940.
  • 29
    Gerberding K, Yoder MC. In vitro comparison of multinucleated giant cell formation from human umbilical cord and adult peripheral blood mononuclear phagocytes. Pediatr Res 1993; 33:1926.
  • 30
    Lay G, Poquet Y, Salek-Peyron P et al. Langhans giant cells from M. tuberculosis-induced human granulomas cannot mediate mycobacterial uptake. J Pathol 2007; 211:7685.
  • 31
    Emile JF, Patey N, Altare F et al. Correlation of granuloma structure with clinical outcome defines two types of idiopathic disseminated BCG infection. J Pathol 1997; 181:2530.
  • 32
    Saunders BM, Frank AA, Orme IM. Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis. Immunology 1999; 98:3248.
  • 33
    Byrd TF. Multinucleated giant cell formation induced by IFN-gamma/IL-3 is associated with restriction of virulent Mycobacterium tuberculosis cell to cell invasion in human monocyte monolayers. Cell Immunol 1998; 188:8996.
  • 34
    Machin GA, Honoré LH, Fanning EA, Molesky M. Perinatally acquired neonatal tuberculosis: report of two cases. Pediatr Pathol 1992; 12:70716.
  • 35
    Gögüs S, Umer H, Akçören Z, Sanal O, Osmanlioglu G, Cimbiş M. Neonatal tuberculosis. Pediatr Pathol 1993; 13:299304.
  • 36
    Kang GH, Chi JG. Congenital tuberculosis – report of an autopsy case. J Korean Med Sci 1990; 5:5964.
  • 37
    Yasui K, Yamazaki M, Miyabayashi M, Tsuno T, Komiyama A. Signal transduction pathway in human polymorphonuclear leukocytes for chemotaxis induced by a chemotactic factor. J Immunol 1994; 152:592228.
  • 38
    Laver J, Duncan E, Abboud M et al. High levels of granulocyte and granulocyte macrophage colony stimulating factors in cord blood of normal full-term infants. J Pediatr 1990; 116:62732.