• 1
    Green PH, Cellier C. Celiac disease. N Engl J Med 2007; 357:173143.
  • 2
    Roschmann E, Wienker TF, Gerok W, Volk BA. T-cell receptor variable genes and genetics susceptibility to celiac disease: an association and linkage study. Gastroenterology 1993; 105:179096.
  • 3
    Alaedini A, Green PH. Narrative review: celiac disease: understanding a complex autoimmune disorder. Ann Intern Med 2005; 142:28998.
  • 4
    Sollid LM, Jabri B. Is celiac disease an autoimmune disorder? Curr Opin Immunol 2005; 17:595600.
  • 5
    Salvati VM, MacDonald TT, Bajaj-Elliott M et al. Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Gut 2002; 50:18690.
  • 6
    Monteleone G, Del Vecchio Blanco G, Palmieri G et al. Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa. Gut 2004; 53:109095.
  • 7
    Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:65569.
  • 8
    Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effect of T-bet in TH1 commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002; 295:33842.
  • 9
    Lametschwandtner G, Biedermann T, Schwärzler C et al. Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. J Allergy Clin Immunol 2004; 113:98794.
  • 10
    Lighvani AA, Frucht DM, Jankovic D et al. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci USA 2001; 98:1513742.
  • 11
    Lugo-Villarino G, Maldonado-Lopez R, Possemato R, Penaranda C, Glimcher LH. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci USA 2003; 100:774954.
  • 12
    Afkarian M, Sedy JR, Yang J et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 2002; 3:54957.
  • 13
    Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002; 285:124.
  • 14
    Stepkowski SM, Chen W, Ross JA, Nagy ZS, Kirken RA. STAT3: an important regulator of multiple cytokine functions. Transplantation 2008; 85:137277.
  • 15
    Schmitz J, Dahmen H, Grimm C et al. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction. J Immunol 2000; 164:84854.
  • 16
    Ivanov II, McKenzie BS, Zhou L, Tadokoro CE et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126:112133.
  • 17
    Mathur AN, Chang HC, Zisoulis DG et al. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 2007; 178:49017.
  • 18
    Yang XO, Pappu BP, Nurieva R et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008; 28:2939.
  • 19
    Kagnoff MF. American Gastroenterology Association Institute. American Gastroenterology Association Institute medical position statement on the diagnosis and management of celiac disease. Gastroenterology 2006; 131:197780.
  • 20
    Weigmann B, Neurath MF. T-bet and mucosal Th1 responses in the gastrointestinal tract. Gut 2002; 51:3013.
  • 21
    Jöhrens K, Anagnostopoulos I, Stein H. T-bet expression patterns in coeliac disease, cryptic and overt enteropathy-type T-cell lymphoma. Histopathology 2005; 47:36874.
  • 22
    Gütgemann I, Fahrer AM, Altman JD, Davis MM, Chien YH. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 1998; 8:66773.
  • 23
    O'Keeffe J, Mills K, Jackson J, Feighery C. T cell proliferation, MHC class II restriction and cytokine products of gliadin-stimulated peripheral blood mononuclear cells (PBMC). Clin Exp Immunol 1999; 117:26976.
  • 24
    Mizrachi A, Broide E, Buchs A et al. Lack of correlation between disease activity and decreased stimulated secretion of IL-10 in lymphocytes from patients with celiac disease. Scand J Gastroenterol 2002; 37:92430.
  • 25
    Anderson RP, Van Heel DA, Tye-Din JA et al. T cells in peripheral blood after gluten challenge in coeliac disease. Gut 2005; 54:121723.
  • 26
    Ben-Horin S, Green PH, Bank I, Chess L, Goldstein I. Characterizing the circulating, gliadin-specific CD4+ memory T cells in patients with celiac disease: linkage between memory function, gut homing and Th1 polarization. J Leukoc Biol 2006; 79:67685.
  • 27
    Gianfrani C, Troncone R, Mugione P et al. Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitome. J Immunol 2003; 170:271926.
  • 28
    Peng SL. The T-box transcription factor T-bet in immunity and autoimmunity. Cell Mol Immunol 2006; 3:8795.
  • 29
    Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE. Regulation of INF-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 2005; 174:678190.
  • 30
    Mazzarella G, MacDonald TT, Salvati VM et al. Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions. Am J Pathol 2003; 162:184555.
  • 31
    Musso A, Dentelli P, Carlino A et al. Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation. Inflamm Bowel Dis 2005; 11:918.
  • 32
    Mangan JK, Rane SG, Kang AD, Amanullah A, Wong BC, Reddy EP. Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation. Blood 2004; 103:4093101.
  • 33
    Corinti S, Albanesi C, La Sala A, Pastore S, Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 2001; 166:431218.
  • 34
    Levy DE, Lee C. What does STAT3 do? J Clin Invest 2002; 109:114348.
  • 35
    Staples KJ, Smallie T, Williams LM et al. IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3. J Immunol 2007; 178:477985.
  • 36
    Hu Y, Hu X, Boumsell L, Ivashkiv LB. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. J Immunol 2008; 180:805765.
  • 37
    VanDeusen JB, Shah MH, Becknell B et al. STAT-1-mediated repression of monocyte interleukin-10 gene expression in vivo. Eur J Immunol 2006; 36:62330.
  • 38
    Stumhofer JS, Silver JS, Laurence A et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol 2007; 8:136371.
  • 39
    O'Garra A, Vieira P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol 2007; 7:42528.
  • 40
    Barisani D, Ceroni S, Meneveri R, Cesana BM, Bardella MT. IL-10 polymorphisms are associated with early-onset celiac disease and severe mucosal damage in patients of Caucasian origin. Genet Med 2006; 8:16974.
  • 41
    Kobayashi T, Okamoto S, Hisamatsu T et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008; 57:168289.
  • 42
    Castellanos-Rubio A, Santin I, Irastorza I, Castaño L, Carlos Vitoria J, Ramon Bilbao J. TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 2009; 42:6973.
  • 43
    Evans HG, Gullick NJ, Kelly S et al. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci USA 2009; 106:623237.
  • 44
    Pène J, Chevalier S, Preisser L et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008; 180:742330.