• 1
    Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347:41729.
  • 2
    Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9:27196.
  • 3
    Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767811.
  • 4
    Kelsall BL, Biron CA, Sharma O, Kaye PM. Dendritic cells at the host–pathogen interface. Nat Immunol 2002; 3:699702.
  • 5
    Iwasaki A, Kelsall BL. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med 1999; 190:22939.
  • 6
    Maric I, Holt PG, Perdue MH, Bienenstock J. Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine. J Immunol 1996; 156:140814.
  • 7
    Rescigno M, Urbano M, Valzasina B et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001; 2:3617.
  • 8
    Macpherson AJ, Uhr T. Compartmentalization of the mucosal immune responses to commensal intestinal bacteria. Ann NY Acad Sci 2004; 1029:3643.
  • 9
    Yoshida M, Claypool SM, Wagner JS et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 2004; 20:76983.
  • 10
    Stagg AJ, Hart AL, Knight SC, Kamm MA. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 2003; 52:15229.
  • 11
    Salazar-Gonzalez RM, Niess JH, Zammit DJ et al. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 2006; 24:62332.
  • 12
    Le BM, Etchart N, Goubier A et al. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity 2006; 24:191201.
  • 13
    Leithauser F, Trobonjaca Z, Moller P, Reimann J. Clustering of colonic lamina propria CD4(+) T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a murine adoptive transfer model. Lab Invest 2001; 81:133949.
  • 14
    Krajina T, Leithauser F, Moller P, Trobonjaca Z, Reimann J. Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur J Immunol 2003; 33:107383.
  • 15
    Baumgart DC, Metzke D, Schmitz J et al. Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut 2005; 54:22836.
  • 16
    Te Velde AA, Van Kooyk, Braat H et al. Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. Eur J Immunol 2003; 33:14351.
  • 17
    Middel P, Raddatz D, Gunawan B, Haller F, Radzun HJ. Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanism. Gut 2006; 55:2207.
  • 18
    Bell SJ, Rigby R, English N et al. Migration and maturation of human colonic dendritic cells. J Immunol 2001; 166:495867.
  • 19
    Hart AL, Al Hassi HO, Rigby RJ et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 2005; 129:5065.
  • 20
    Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006; 55:74953.
  • 21
    Singleton JW. Clinical activity assessment in inflammatory bowel disease. Dig Dis Sci 1987; 32:42S5S.
  • 22
    Patterson S, Gross J, Bedford P, Knight SC. Morphology and phenotype of dendritic cells from peripheral blood and their productive and non-productive infection with human immunodeficiency virus type 1. Immunology 1991; 72:3617.
  • 23
    Dzionek A, Fuchs A, Schmidt P et al. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 2000; 165:603746.
  • 24
    Rutter M, Saunders B, Wilkinson K et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 2004; 126:4519.
  • 25
    Gupta RB, Harpaz N, Itzkowitz S et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 2007; 133:1099105.
  • 26
    Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004; 5:121926.
  • 27
    Siu LL, Chan JK, Kwong YL. Natural killer cell malignancies: clinicopathologic and molecular features. Histol Histopathol 2002; 17:53954.
  • 28
    Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D. TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood 2003; 101:50079.
  • 29
    Chaperot L, Bendriss N, Manches O et al. Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood 2001; 97:321017.
  • 30
    Miranti CK, Brugge JS. Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 2002; 4: E8390.
  • 31
    Cella M, Fuchs A, Vermi W et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 2009; 457:7225.
  • 32
    Mela CM, Steel A, Lindsay J, Gazzard BG, Gotch FM, Goodier MR. Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1-infected individuals. AIDS 2007; 21:217782.
  • 33
    Dalbeth N, Gundle R, Davies RJ, Lee YC, McMichael AJ, Callan MF. CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J Immunol 2004; 173:641826.
  • 34
    Chan A, Hong DL, Atzberger A et al. CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J Immunol 2007; 179:8994.
  • 35
    Homann D, Jahreis A, Wolfe T et al. CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 2002; 16:40315.
  • 36
    Hanna J, Gonen-Gross T, Fitchett J et al. Novel APC-like properties of human NK cells directly regulate T cell activation. J Clin Invest 2004; 114:161223.
  • 37
    Leon F, Roldan E, Sanchez L, Camarero C, Bootello A, Roy G. Human small-intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology 2003; 125:34556.
  • 38
    Chinen H, Matsuoka K, Sato T et al. Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells. Gastroenterology 2007; 133:55973.
  • 39
    Sanos SL, Bui VL, Mortha A et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 2009; 10:8391.
  • 40
    Fuss IJ, Heller F, Boirivant M et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004; 113:14907.
  • 41
    Hanna J, Wald O, Goldman-Wohl D et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells. Blood 2003; 102:156977.
  • 42
    Martin-Fontecha A, Thomsen LL, Brett S et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 2004; 5:12605.
  • 43
    Perez-Villar JJ, Zapata JM, Melero I, Postigo A, Sanchez-Madrid E, Lopez-Botet M. Expression and function of alpha 4/beta 7 integrin on human natural killer cells. Immunology 1996; 89:96104.