S. Sarkar and L. A. Cooney contributed equally to this manuscript.
The role of T helper type 17 cells in inflammatory arthritis
Article first published online: 25 AUG 2009
© 2009 British Society for Immunology
Clinical & Experimental Immunology
Volume 159, Issue 3, pages 225–237, March 2010
How to Cite
Sarkar, S., Cooney, L. A. and Fox, D. A. (2010), The role of T helper type 17 cells in inflammatory arthritis. Clinical & Experimental Immunology, 159: 225–237. doi: 10.1111/j.1365-2249.2009.04016.x
- Issue published online: 15 JAN 2010
- Article first published online: 25 AUG 2009
- Accepted for publication 14 August 2009
- collagen arthritis;
- rheumatoid arthritis;
- T lymphocytes
While T cells have been implicated in the pathogenesis of inflammatory arthritis for more than three decades, the focus on the T helper type 17 (Th17) subset of CD4 T cells and their secreted cytokines, such as interleukin (IL)-17, is much more recent. Proinflammatory actions of IL-17 were first identified in the 1990s, but the delineation of a distinct Th17 subset in late 2005 has sparked great interest in the role of these cells in a broad range of immune-mediated diseases. This review summarizes current understanding of the role of Th17 cells and their products in both animal models of inflammatory arthritis and human immune-driven arthritides.