• 1
    Prescott SL, Macaubas C, Holt BJ et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998; 160:47307.
  • 2
    Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the trial of infant probiotic supplementation. Paediatr Perinat Epidemiol 2007; 21 (Suppl. 3):238.
  • 3
    Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001; 108:51620.
  • 4
    Renz-Polster H, David MR, Buist AS et al. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy 2005; 35:146672.
  • 5
    Newburg DS. Oligosaccharides in human milk and bacterial colonization. J Pediatr Gastroenterol Nutr 2000; 30 (Suppl. 2):S817.
  • 6
    Matsuki T, Watanabe K, Tanaka R, Fukuda M, Oyaizu H. Distribution of bifidobacterial species in human intestinal microflora examined with 16S rRNA-gene-targeted species-specific primers. Appl Environ Microbiol 1999; 65:450612.
  • 7
    Harmsen HJ, Wildeboer-Veloo AC, Raangs GC et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000; 30:617.
  • 8
    Yoshioka H, Iseki K, Fujita K. Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants. Pediatrics 1983; 72:31721.
  • 9
    Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001; 107:12934.
  • 10
    Özdemir Ö. Gut flora development in infancy and its effect on immune system. Çocuk Enf Derg (J Pediatr Inf) 2009; 3:2023.
  • 11
    Metchnikoff E. The prolongation of life: optimistic studies. London: G. P. Putnam & Sons, 1907.
  • 12
    Food and Agriculture Organization, World Health Organization (FAO/WHO). Report of Joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. FAO/WHO Report no. 10-1-2001. WHO INT; Córdoba, Argentina.
  • 13
    Özdemir Ö. Any benefits of probiotics in allergic disorders? Allergy Asthma Proc 2010; 31:19.
  • 14
    Guarner F, Perdigon G, Corthier G, Salminen S, Koletzko B, Morelli L. Should yoghurt cultures be considered probiotic? Br J Nutr 2005; 93:7836.
  • 15
    Walker WA. Mechanisms of action of probiotics. Clin Infect Dis 2008; 46 (Suppl. 2):S8791.S144–51.
  • 16
    Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997; 159:173945.
  • 17
    Viljanen M, Kuitunen M, Haahtela T, Juntunen-Backman K, Korpela R, Savilahti E. Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. Pediatr Allergy Immunol 2005; 16:6571.
  • 18
    Isolauri E. Studies on Lactobacillus GG in food hypersensitivity disorders. Nutr Today Suppl 1996; 31:285315.
  • 19
    Cebra JJ. Influences of microbiota on intestinal immune system development. Am J Clin Nutr 1999; 69:1046S51S.
  • 20
    Malin MV, Korhonen H, Syvaoja EL et al. Dietary therapy with Lactobacillus GG, bovine colostrum or bovine immune colostrum in patients with juvenile chronic arthritis: evaluation of effect on gut defense mechanisms. Inflammopharmacology 1997; 5:21936.
  • 21
    Pessi T, Isolauri E, Sutas Y, Kankaanranta H, Moilanen E, Hurme M. Suppression of T cell activation by Lactobacillus rhamnosus GG-degraded bovine casein. Immunopharmacology 2001; 1:2118.
  • 22
    Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res 1992; 32:1414.
  • 23
    Ruemmele FM, Bier D, Marteau P et al. Clinical evidence for immunomodulatory effects of probiotic bacteria. J Pediatr Gastroenterol Nutr 2009; 48:12641.
  • 24
    Christensen HR, Frokiaer H, Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 2002; 168:1718.
  • 25
    Niers LE, Timmerman HM, Rijkers GT et al. Identification of strong interleukin-10 inducing lactic acid bacteria which downregulate T helper type 2 cytokines. Clin Exp Allergy 2005; 35:14819.
  • 26
    Maassen CB, Van Holten-Neelen C, Balk F et al. Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains. Vaccine 2000; 18:261323.
  • 27
    Kim JY, Choi YO, Ji GE. Effect of oral probiotics (Bifidobacterium lactis AD 011 and Lactobacillus acidophilus AD 031) administration on ovalbumin-induced food allergy mouse model. J Microbiol Biotechnol 2008; 18:1393400.
  • 28
    Takahashi N, Kitazawa H, Iwabuchi N et al. Immunostimulatory oligodeoxynucleotide from Bifidobacterium longum suppresses Th2 immune responses in a murine model. Clin Exp Immunol 2006; 145:1308.
  • 29
    Gill H, Prasad J. Probiotics, immunomodulation, and health benefits. Adv Exp Med Biol 2008; 606:42354.
  • 30
    Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J Gastroenterol 2009; 44:2646.
  • 31
    Sistek D, Kelly R, Wickens K, Stanley T, Fitzharris P, Crane J. Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clin Exp Allergy 2006; 36:62933.
  • 32
    Salminen SJ, Gueimonde M, Isolauri E. Probiotics that modify disease risk. J Nutr 2005; 135:12948.
  • 33
    Kruisselbrink A, Heijne Den Bak-Glashouwer MJ, Havenith CE, Thole JE, Janssen R. Recombinant Lactobacillus plantarum inhibits house dust mite-specific T-cell responses. Clin Exp Immunol 2001; 126:28.
  • 34
    Niers LE, Hoekstra MO, Timmerman HM et al. Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells. Clin Exp Immunol 2007; 149:34452.
  • 35
    Mohamadzadeh M, Olson S, Kalina WV et al. Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci USA 2005; 102:22805.
  • 36
    Hart AL, Lammers K, Brigidi P et al. Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 2004; 53:16029.
  • 37
    Braat H, Van Den Brande J, Van Tol E, Hommes D, Peppelenbosch M, Van Deventer S. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. Am J Clin Nutr 2004; 80:161825.
  • 38
    Smits HH, Engering A, Van Der Kleij D et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 2005; 115:12607.
  • 39
    Hoarau C, Lagaraine C, Martin L, Velge-Roussel F, Lebranchu Y. Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway. J Allergy Clin Immunol 2006; 117:696702.
  • 40
    Forsythe P, Inman MD, Bienenstock J. Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice. Am J Respir Crit Care Med 2007; 175:5619.
  • 41
    Viljanen M, Pohjavuori E, Haahtela T et al. Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema–dermatitis syndrome. J Allergy Clin Immunol 2005; 115:12549.
  • 42
    Torii A, Torii S, Fujiwara S, Tanaka H, Inagaki N, Nagai H. Lactobacillus acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines. Allergol Int 2007; 56:293301.
  • 43
    Feleszko W, Jaworska J, Rha RD et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy 2007; 37:498505.
  • 44
    Marschan E, Kuitunen M, Kukkonen K et al. Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation. Clin Exp Allergy 2008; 38:6118.
  • 45
    Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001; 357:10769.
  • 46
    Kopp MV, Hennemuth I, Heinzmann A, Urbanek R. Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. Pediatrics 2008; 121:e8506.
  • 47
    Wickens K, Black PN, Stanley TV et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2008; 122:78894.
  • 48
    Viljanen M, Savilahti E, Haahtela T et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 2005; 60:494500.
  • 49
    Rosenfeldt V, Benfeldt E, Nielsen SD et al. Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 2003; 111:38995.
  • 50
    Kuitunen M, Kukkonen K, Juntunen-Backman K et al. Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort. J Allergy Clin Immunol 2009; 123:33541.
  • 51
    Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol 2008; 9:93103.
  • 52
    Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 2007; 4:CD006475.
  • 53
    Vliagoftis H, Kouranos VD, Betsi GI, Falagas ME. Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials. Ann Allergy Asthma Immunol 2008; 101:5709.
  • 54
    Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, Murrell DF, Tang ML. Probiotics for the treatment of eczema: a systematic review. Clin Exp Allergy 2009; 39:111727.
  • 55
    Lee J, Seto D, Bielory L. Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. J Allergy Clin Immunol 2008; 121:11621.
  • 56
    Isolauri E, Rautava S, Kalliomäki M, Kirjavainen P, Salminen S. Role of probiotics in food hypersensitivity. Curr Opin Allergy Clin Immunol 2002; 2:26371.
  • 57
    Majamaa H, Isolauri E. Probiotics. A novel approach in the management of food allergy. J Allergy Clin Immunol 1997; 99:17985.
  • 58
    Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy 2000; 30:160410.
  • 59
    Di Felice G, Barletta B, Butteroni C et al. Use of probiotic bacteria for prevention and therapy of allergic diseases: studies in mouse model of allergic sensitization. J Clin Gastroenterol 2008; 42 (Suppl. 3):S1302.
  • 60
    Shida K, Takahashi R, Iwadate E et al. Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin Exp Allergy 2002; 32:56370.
  • 61
    Hol J, Van Leer EH, Elink Schuurman BE et al. The acquisition of tolerance toward cow's milk through probiotic supplementation: a randomized, controlled trial. J Allergy Clin Immunol 2008; 121:144854.
  • 62
    Taylor A, Dunstan J, Prescott S. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 2007; 119:18491.
  • 63
    Soh SE, Aw M, Gerez I et al. Probiotic supplementation in the first 6 months of life in at risk Asian infants – effects on eczema and atopic sensitization at the age of 1 year. Clin Exp Allergy 2009; 39:5718.
  • 64
    Kopp MV, Salfeld P. Probiotics and prevention of allergic disease. Curr Opin Clin Nutr Metab Care 2009; 12:298303.
  • 65
    Peng GC, Hsu CH. The efficacy and safety of heat-killed Lactobacillus paracasei for treatment of perennial allergic rhinitis induced by house-dust mite. Pediatr Allergy Immunol 2005; 16:4338.
  • 66
    Ivory K, Chambers SJ, Pin C, Prieto E, Arqués JL, Nicoletti C. Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis. Clin Exp Allergy 2008; 38:12829.
  • 67
    Giovannini M, Agostoni C, Riva E et al.; Felicita Study Group. A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatr Res 2007; 62:21520.
  • 68
    Kawase M, He F, Kubota A et al. Effect of fermented milk prepared with two probiotic strains on Japanese cedar pollinosis in a double-blind placebo-controlled clinical study. Int J Food Microbiol 2009; 128:42934.
  • 69
    Morita H, He F, Kawase M et al. Preliminary human study for possible alteration of serum immunoglobulin E production in perennial allergic rhinitis with fermented milk prepared with Lactobacillus gasseri TMC0356. Microbiol Immunol 2006; 50:7016.
  • 70
    Xiao JZ, Kondo S, Yanagisawa N et al. Effect of probiotic Bifidobacterium longum BB536 [corrected] in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial. J Invest Allergol Clin Immunol 2006; 16:8693.
  • 71
    Xiao JZ, Kondo S, Yanagisawa N et al. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin Exp Allergy 2006; 36:142535.
  • 72
    Tamura M, Shikina T, Morihana T et al. Effects of probiotics on allergic rhinitis induced by Japanese cedar pollen: randomized double-blind, placebo-controlled clinical trial. Int Arch Allergy Immunol 2007; 143:7582.
  • 73
    Blümer N, Sel S, Virna S et al. Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring. Clin Exp Allergy 2007; 37:34857.
  • 74
    Repa A, Grangette C, Daniel C et al. Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy. Vaccine 2003; 22:8795.
  • 75
    Karimi K, Inman MD, Bienenstock J, Forsythe P. Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am J Respir Crit Care Med 2009; 179:18693.
  • 76
    Stockert K, Schneider B, Porenta G, Rath R, Nissel H, Eichler I. Laser acupuncture and probiotics in school age children with asthma: a randomized, placebo-controlled pilot study of therapy guided by principles of traditional Chinese medicine. Pediatr Allergy Immunol 2007; 18:1606.
  • 77
    Moreira A, Kekkonen R, Korpela R, Delgado L, Haahtela T. Allergy in marathon runners and effect of Lactobacillus GG supplementation on allergic inflammatory markers. Respir Med 2007; 101:112331.
  • 78
    Helin T, Haahtela S, Haahtela T. No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study. Allergy 2002; 57:2436.
  • 79
    Food and Agriculture Organization, World Health Organization (FAO/WHO). The Food and Agriculture Organization of the United Nations and the World Health Organization Joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. FAO/WHO Report no. 4-30-2002. WHO INT; London, Ontario, Canada.
  • 80
    Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr 2004; 38:4578.
  • 81
    Salminen S, Von Wright A, Morelli L et al. Demonstration of safety of probiotics: a review. Int J Food Microbiol 1998; 44:93106.
  • 82
    Taylor AL, Hale J, Wiltschut J, Lehmann H, Dunstan JA, Prescott SL. Effects of probiotic supplementation for the first 6 months of life on allergen- and vaccine-specific immune responses. Clin Exp Allergy 2006; 36:122735.
  • 83
    Isolauri E, Joensuu J, Suomalainen H, Luomala M, Vesikari T. Improved immunogenicity of oral Dx RRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine 1995; 13:3102.
  • 84
    Lin JS, Chiu YH, Lin NT et al. Different effects of probiotic species/strains on infections in preschool children: a double-blind, randomized, controlled study. Vaccine 2009; 27:10739.
  • 85
    Isolauri E, Salminen S; Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report. Probiotics: use in allergic disorders: a Nutrition, Allergy, Mucosal Immunology, and Intestinal Microbiota (NAMI) Research Group Report. J Clin Gastroenterol 2008; 42 (Suppl. 2):S916.