See Appendix for a complete list of members of the T-Cell Workshop Committee of the Immunology of Diabetes Society.
Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes
Article first published online: 15 SEP 2010
© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology
Clinical & Experimental Immunology
Volume 162, Issue 2, pages 197–209, November 2010
How to Cite
Mannering, S. I., Wong, F. S., Durinovic-Belló, I., Brooks-Worrell, B., Tree, T. I., Cilio, C. M., Schloot, N. C., Mallone, R. and on behalf of the Immunology of Diabetes Society T-Cell Workshop Committee (2010), Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes. Clinical & Experimental Immunology, 162: 197–209. doi: 10.1111/j.1365-2249.2010.04237.x
- Issue published online: 8 OCT 2010
- Article first published online: 15 SEP 2010
- Accepted for publication 7 July 2010
- T cell assays;
- type 1 diabetes
Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently required to guide the development of antigen-based therapies intended to prevent, or cure, T1D. Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed.