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Keywords:

  • allergic rhinitis;
  • desensitization;
  • drug desensitization;
  • immunotherapy;
  • hymenoptera venom

ARTICLES PUBLISHED IN THIS CLINICAL IMMUNOLOGY REVIEW SERIES

Allergy in childhood, allergy diagnosis by use of the clinical immunology laboratory, anaphylaxis, angioedema, desensitization, management of pulmonary disease in primary antibody deficiency, recurrent infections in childhood, recurrent infections in adulthood, recurrent oro-genital ulceration, recurrent superficial abscesses, urticaria, vasculitis/CTD

Summary

Allergen immunotherapy describes the treatment of allergic disease through administration of gradually increasing doses of allergen. This form of immune tolerance induction is now safer, more reliably efficacious and better understood than when it was first formally described in 1911. In this paper the authors aim to summarize the current state of the art in immunotherapy in the treatment of inhalant, venom and drug allergies, with specific reference to its practice in the United Kingdom. A practical approach has been taken, with reference to current evidence and guidelines, including illustrative protocols and vaccine schedules. A number of novel approaches and techniques are likely to change considerably the way in which we select and treat allergy patients in the coming decade, and these advances are previewed.