Sulphilimine/Sulfilimine cross-links in Goodpasture's disease

Authors

  • R. Vanacore,

    Corresponding author
    1. Center for Matrix Biology and Division of Nephrology & Hypertension, Department of Medicine, and Departments of
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  • V. Pedchenko,

    1. Center for Matrix Biology and Division of Nephrology & Hypertension, Department of Medicine, and Departments of
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  • G. Bhave,

    1. Center for Matrix Biology and Division of Nephrology & Hypertension, Department of Medicine, and Departments of
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  • B. G. Hudson

    1. Center for Matrix Biology and Division of Nephrology & Hypertension, Department of Medicine, and Departments of
    2. Pathology
    3. Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA
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R. Vanacore, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, S-3221 MCN, 1161 21st Avenue South, Nashville, TN 37232-2372, USA.
E-mail: roberto.vanacore@vanderbilt.edu

Summary

The sulphilimine/sulfilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine/sulfilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.

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