Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation
Article first published online: 1 DEC 2011
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology
Clinical & Experimental Immunology
Volume 167, Issue 1, pages 59–66, January 2012
How to Cite
Patil, S. U. and Shreffler, W. G. (2012), Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation. Clinical & Experimental Immunology, 167: 59–66. doi: 10.1111/j.1365-2249.2011.04503.x
- Issue published online: 1 DEC 2011
- Article first published online: 1 DEC 2011
- Accepted manuscript online: 12 OCT 2011 08:14AM EST
- Accepted for publication 29 September 2011
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES
Metabolic Diseases, Host Responses, Cancer, Autoinflammatory Diseases, Type 1 diabetes and viruses.
Allergen-specific immunotherapy is an effective clinical treatment for hypersensitivity to many allergens. Studies of basophils during immunotherapy have provided insight into underlying immune mechanisms and support the potential use of basophil activation as a biomarker of clinical outcomes. This review examines the evidence for different pathways of basophil modulation associated with various forms of immunotherapy. Better understanding the molecular mechanisms of basophil activation and desensitization and the relationship between suppression of these effector cells to clinical outcomes holds promise for further development and improvement in potential therapies for allergic diseases.