These authors contributed equally to this manuscript.
Immunology in the clinic review series; focus on cancer: multiple roles for the immune system in oncogene addiction
Article first published online: 11 JAN 2012
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology
Clinical & Experimental Immunology
Volume 167, Issue 2, pages 188–194, February 2012
How to Cite
Bachireddy, P., Rakhra, K. and Felsher, D. W. (2012), Immunology in the clinic review series; focus on cancer: multiple roles for the immune system in oncogene addiction. Clinical & Experimental Immunology, 167: 188–194. doi: 10.1111/j.1365-2249.2011.04514.x
- Issue published online: 11 JAN 2012
- Article first published online: 11 JAN 2012
- Accepted manuscript online: 31 OCT 2011 10:32AM EST
- Accepted for publication 24 October 2011
- tumour antigens
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES
Metabolic Diseases, Host Responses, Allergies, Autoinflammatory Diseases, Type 1 diabetes and viruses.
Despite complex genomic and epigenetic abnormalities, many cancers are irrevocably dependent on an initiating oncogenic lesion whose restoration to a normal physiological activation can elicit a dramatic and sudden reversal of their neoplastic properties. This phenomenon of the reversal of tumorigenesis has been described as oncogene addiction. Oncogene addiction had been thought to occur largely through tumour cell-autonomous mechanisms such as proliferative arrest, apoptosis, differentiation and cellular senescence. However, the immune system plays an integral role in almost every aspect of tumorigenesis, including tumour initiation, prevention and progression as well as the response to therapeutics. Here we highlight more recent evidence suggesting that oncogene addiction may be integrally dependent upon host immune-mediated mechanisms, including specific immune effectors and cytokines that regulate tumour cell senescence and tumour-associated angiogenesis. Hence, the host immune system is essential to oncogene addiction.