Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation
Article first published online: 30 JAN 2012
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology
Clinical & Experimental Immunology
Volume 167, Issue 3, pages 369–381, March 2012
How to Cite
Mankan, A. K., Kubarenko, A. and Hornung, V. (2012), Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation. Clinical & Experimental Immunology, 167: 369–381. doi: 10.1111/j.1365-2249.2011.04534.x
- Issue published online: 30 JAN 2012
- Article first published online: 30 JAN 2012
- Accepted manuscript online: 25 NOV 2011 01:37PM EST
- Accepted for publication 18 November 2011
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES
Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases.
Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and molecular platforms that process this signal to trigger an appropriate effector response. Pattern recognition receptors can engage different signalling cascades that lead to proinflammatory gene expression. At the same time, transcription-independent events such as activation of proteases and/or phagocytosis are also initiated. The inflammasome pathway constitutes a signalling platform that leads to the activation of so-called inflammatory caspases, most notably caspase-1, which plays a pivotal role in the cleavage and thus maturation of proinflammatory cytokines, but also in the induction of pyroptosis, a special type of cell death. In this review we elaborate on the currently known inflammasome complexes with a special focus on the mechanism behind their activation. Understanding these mechanisms could provide important information regarding the potential signalling nodes that might be targeted for therapeutic intervention.