Both authors contributed equally to this work.
Human mucosal CD4+ T cells but not blood CD4+ T cells respond vigorously towards CD28 engagement
Article first published online: 2 MAR 2012
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology
Clinical & Experimental Immunology
Volume 168, Issue 1, pages 87–94, April 2012
How to Cite
Schröder-Braunstein, J., Pavlov, V., Giese, T., Heidtmann, A., Wentrup, S., Lasitschka, F., Winter, J., Ulrich, A., Engelke, A., Al Saeedi, M. and Meuer, S. (2012), Human mucosal CD4+ T cells but not blood CD4+ T cells respond vigorously towards CD28 engagement. Clinical & Experimental Immunology, 168: 87–94. doi: 10.1111/j.1365-2249.2011.04539.x
E-mail address of senior author: email@example.com
- Issue published online: 2 MAR 2012
- Article first published online: 2 MAR 2012
- Accepted manuscript online: 28 NOV 2011 11:13AM EST
- Accepted for publication 21 November 2011
Fig. S1. Stimulation by a single CD28 monoclonal antibody (mAb) induces proliferation in lamina propria T lymphocytes (LPT) but not peripheral blood T lymphocytes (PBT). CD4+ PBT and LPT were cultured in the presence or absence of two different concentrations of the CD28 mAb 248 [immunoglobulin (Ig)M; 10 and 5 μg/ml] or the CD3 mAb muromonab-CD3 (OKT-3) (0·5 and 0·05 μg/ml) for 72 h. Proliferation was determined by [3H]-thymidine incorporation. Shown are two independent experiments using cells from two different patients. Data are represented as mean ± standard error of the mean of triplicate cultures.
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