Original Article

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T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis

  1. S. Wang1,*,
  2. S. E. Baidoo1,
  3. Y. Liu1,
  4. C. Zhu1,
  5. J. Tian1,
  6. J. Ma1,
  7. J. Tong1,
  8. J. Chen1,
  9. X. Tang1,
  10. H. Xu1,
  11. L. Lu2

Article first published online: 3 DEC 2012

DOI: 10.1111/j.1365-2249.2012.04670.x

Issue

Clinical & Experimental Immunology

Clinical & Experimental Immunology

Volume 171, Issue 1, pages 63–68, January 2013

Additional Information

How to Cite

Wang, S., Baidoo, S. E., Liu, Y., Zhu, C., Tian, J., Ma, J., Tong, J., Chen, J., Tang, X., Xu, H. and Lu, L. (2013), T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis. Clinical & Experimental Immunology, 171: 63–68. doi: 10.1111/j.1365-2249.2012.04670.x

Author Information

  1. 1

    Department of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang, China

  2. 2

    Department of Pathology, Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China

* Correspondence: S. Wang, Department of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212002, Jiangsu, China.
E-mail: sjwjs@ujs.edu.cn

Publication History

  1. Issue published online: 3 DEC 2012
  2. Article first published online: 3 DEC 2012
  3. Accepted manuscript online: 27 AUG 2012 10:49PM EST
  4. Manuscript Accepted: 22 AUG 2012

Funded by

  • National Natural Science Foundation of China. Grant Numbers: 30871193, 81072453, 30972748, 31100648, 30910103087
  • Health Department Foundation of Jiangsu Province. Grant Number: H200952
  • Graduate Student Research and Innovation Program of Jiangsu Province. Grant Numbers: CXLX11_0608, CXZZ12_0710
  • Jiangsu Province Qinglan Project
  • Top Talent Program of Jiangsu University

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Keywords:

  • Hashimoto's thyroiditis;
  • leptin;
  • Th17 cells

Summary

Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the role of leptin and T helper type 17 (Th17) cells in Hashimoto's thyroiditis patients. Twenty-seven patients with Hashimoto's thyroiditis (HT) and 20 healthy controls were enrolled into the current study. A modest increase of plasma leptin in HT patients and the CD4+ T cell-derived leptin from HT patients was stronger than that from healthy controls. In HT patients, there are no statistically significant correlations between plasma leptin concentrations and the percentage of Th17 cells or the level of retinoic acid-related orphan receptor γt (RORγt), but strong positive correlations were observed between CD4+ T cell-derived leptin and the percentage of Th17 cells or the level of RORγt mRNA, and additionally significantly up-regulated leptin, interleukin (IL)17 and RORγt mRNA levels in the thyroid tissue. Furthermore, neutralization of leptin decreases the frequency of Th17 cells in vitro. Current study has revealed an increased leptin involvment in Hashimoto's thyroiditis associated with an increased number of Th17 cells.

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