Impaired natural killer cell-induced antibody-dependent cell-mediated cytotoxicity is associated with human immunodeficiency virus-1 disease progression
Article first published online: 3 DEC 2012
© 2012 The Authors Clinical and Experimental Immunology © 2012 British Society for Immunology
Clinical & Experimental Immunology
Volume 171, Issue 1, pages 107–116, January 2013
How to Cite
Jia, M., Li, D., He, X., Zhao, Y., Peng, H., Ma, P., Hong, K., Liang, H. and Shao, Y. (2013), Impaired natural killer cell-induced antibody-dependent cell-mediated cytotoxicity is associated with human immunodeficiency virus-1 disease progression. Clinical & Experimental Immunology, 171: 107–116. doi: 10.1111/j.1365-2249.2012.04672.x
- Issue published online: 3 DEC 2012
- Article first published online: 3 DEC 2012
- Accepted manuscript online: 20 SEP 2012 07:56AM EST
- Manuscript Accepted: 4 SEP 2012
- China Ministry of Science and Technology. Grant Number: 2008ZX10001-010, 2012ZX10001-008
- National Nature Science Foundation of China. Grant Number: 81020108030
Figure S1. natural killer (NK) cell receptor expressions were determined in each NK subset from FPDs. (A,B) NK activating receptors NKG2C and NKP46 were elevated in the CD16posCD56dim NK subset during human immunodeficiency virus (HIV) infection. (C,D) Inhibitory receptors NKG2A and CD158a were also elevated in the CD16posCD56dim NK subset of HIV-positive individuals. No significant difference was found among different subgroups in the CD56bright subset except CD158a expression. In CD16posCD56neg subset, however, we observed lower expression of NKP46 in HIV-positive groups compared to healthy controls. In contrast, the expression of NKG2A was higher in HIV-positive groups compared to healthy controls, and the level of CD158a in CD4low group was also higher than healthy controls.
Table S1. Detailed information of human leucocyte antigen (HLA) alleles in 41 human immunodeficiency virus (HIV)-1 infected former plasma donors (FPDs).
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