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Fig. S1. Overlap of positivity for the four autoantibody specificities tested at baseline. Prevalence data are expressed as percentage of the total number of relatives (n = 394). Reference: Oliveros, J. C. (2007) VENNY. An interactive tool for comparing lists with Venn diagrams. http://bioinfogp.cnb.csic.es/tools/venny/index.html

Fig. S2. Diabetes-free survival of relatives positive for insulinoma antigen 2A (IA-2A) (a) or zinc transporter 8 autoantibodies (ZnT8A) (b) according to the number of other antibody specificities present (n = 0: purple, n = 1: red, n = 2: blue, n = 3: green). The fraction of relatives progressing to diabetes during follow-up is indicated above each arm in the two panels. *P-value for comparison of IA-2A+ (a) or ZnT8A+ (b) relatives presenting one, two or three additional antibody specificities (log-rank test).**P-value for comparison of solitary IA-2A+ (panel a) or ZnT8+ (panel b) relatives versus relatives positive for at least one additional antibody (n = 1, n = 2 and n = 3) taken together (log-rank test).

Fig. S3. Diabetes-free survival of relatives positive for insulinoma antigen 2A (IA-2A) (a) and those positive for zinc transporter 8 autoantibodies (ZnT8A) (b) according to the titre of IA-2A and ZnT8A, respectively: tertile 1 (green), tertile 2 (blue), tertile 3 (red). P-values by log-rank test. The fraction of relatives progressing to diabetes during follow-up is indicated above each arm in the two panels.

Table S1. Five-year progression to type 1 diabetes according to antibody type in antibody-positive relatives (0–39 years).

Appendix S1. List of the current members of the Belgian Diabetes Registry who participated in the recruitment of relatives and the handling of samples.

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