The potential value of immuno-isoelectric focusing in the diagnosis and management of solitary plasmacytoma



Summary Immuno-isoelectric focusing is a highly sensitive method of detecting small quantities of monoclonal protein. We have previously reported the first demonstration of serum paraprotein in non-secretory myeloma using this technique (Sheehan et al. 1985). We now report a case of solitary plasmacytoma where this technique revealed a small concentration of serum paraprotein when conventional techniques failed, and discuss the potential value of immuno-isolectric focusing in plasma cell dyscrasia, with limited tumour cell mass.