EFFECT OF lα-HYDROXYVITAMIN D3 AND 1,25-DIHYDROXYVITAMIN D3 ON INTESTINE AND BONE IN GLUCOCORTICOID-TREATED PATIENTS

Authors

  • B. LUND,

    Corresponding author
    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author
  • R. B. ANDERSEN,

    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author
  • T. FRIIS,

    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author
  • L. HJORTH,

    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author
  • F. S. JØRGENSEN,

    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author
  • A. W. NORMAN,

    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author
  • O. H. SØRENSEN

    1. Medical Department E, Fredenksberg Hospital, Medical Department and Department of Physical Medicine, Hvidovre Hospital, Copenhagen, Denmark, and Department of Biochemistry, University of California, Riverside, U.S.A.
    Search for more papers by this author

Dr B. Lund, Medical Department E. Frederiksberg Hospital. Copenhagen, Denmark.

SUMMARY

The effect of lα-hydroxyvitamin D3 (lα-OHD3) and 1,25-dihydroxyvitamin D3 (1,25–(OH)2D3) on the intestinal calcium absorption was studied in twenty patients with rheumatoid arthritis treated with prednisone at daily doses of 5–15mg for 1/2–20 years. The fractional calcium absorption, measured before and after the treatment with the vitamin D compounds, increased in nineteen of the twenty patients. This was, however, accompanied by marked rises in the urinary calcium excretion. There was no correlation between the fractional calcium absorption and the duration of the prednisone treatment or the doses given.

Ancillary