SIMULTANEOUS STUDY OF CORTISOL, GROWTH HORMONE AND PROLACTIN NYCTOHEMERAL VARIATIONS IN NORMAL AND OBESE SUBJECTS. INFLUENCE OF PROLONGED FASTING IN OBESITY
Article first published online: 17 MAR 2008
Volume 9, Issue 1, pages 15–26, July 1978
How to Cite
COPINSCHI, G., LAET, M.-H. D., BRION, J. P., LECLERCQ, R., L'HERMITE, M., ROBYN, C., VIRASORO, E. and CAUTER, E. V. (1978), SIMULTANEOUS STUDY OF CORTISOL, GROWTH HORMONE AND PROLACTIN NYCTOHEMERAL VARIATIONS IN NORMAL AND OBESE SUBJECTS. INFLUENCE OF PROLONGED FASTING IN OBESITY. Clinical Endocrinology, 9: 15–26. doi: 10.1111/j.1365-2265.1978.tb03568.x
- Issue published online: 17 MAR 2008
- Article first published online: 17 MAR 2008
- (Received 1 August 1977; revised I7 October 1977; accepted 3 January 1978)
Hourly integrated concentrations (IC) of growth hormone (GH), prolactin (PRL) and cortisol were determined by a continuous sampling procedure in six obese women, before and at the end of a 12 day fast, and in eight normal controls under basal conditions. Hormonal 24 h IC and nyctohemeral variations were calculated from these data. Nyctohemeral rhythms were investigated by the periodogram method.
A significant increase over basal values of 24 h IC of PRL, GH and cortisol was observed at the end of the fasting period. Nyctohemeral variations-but not nyctohemeral rhythm-of IC-GH were found in normal subjects. They were abolished in obese patients under basal conditions but restored during fasting. The circadian rhythm of cortisol was not altered in obesity. A shift of the normal nyctohemeral rhythm of PRL was observed in obese patients, but the normal pattern was restored during fasting.