St James' University Hospital, Beckett Street, Leeds LS9 7TF.
SENSORY THRESHOLDS AND MOTOR RESPONSIVENESS IN THYROID DISEASE: THEIR RESPONSES TO TREATMENT AND WARMING
Article first published online: 17 MAR 2008
Volume 23, Issue 1, pages 17–23, July 1985
How to Cite
O'MALLEY, B. P., ABBOTT, R. J., TIMSON, L., BECK, A. D. and ROSENTHAL, F. D. (1985), SENSORY THRESHOLDS AND MOTOR RESPONSIVENESS IN THYROID DISEASE: THEIR RESPONSES TO TREATMENT AND WARMING. Clinical Endocrinology, 23: 17–23. doi: 10.1111/j.1365-2265.1985.tb00178.x
- Issue published online: 17 MAR 2008
- Article first published online: 17 MAR 2008
- (Received 6 September 1984; returned for revision 15 October 1984; finally revision 5 January 1985 accepted 22 January 1985)
It has been our clinical observation that patients with hypothyroidism are relatively insensitive to the discomfort of venepuncture, whereas thyrotoxic patients seem to have a heightened sensitivity. In an initial study we have measured the sensory thresholds of perception along with motor responsiveness in hypothyroid, thyrotoxic and euthyroid subjects, employing a simple and readily reproducible technique. Sensory thresholds were elevated and motor responsiveness impaired in hypothyroid subjects as compared to euthyroid controls. In thyrotoxic subjects, motor responsiveness was significantly enhanced, but sensory thresholds did not differ from control values. In a subsequent study the threshold abnormalities of thyroid dysfunction were corrected by rendering the patients euthyroid with appropriate therapy. Warming a further group of untreated hypothyroid patients produced a similar improvement in motor responsiveness to that seen in the L-thyroxine-treated group, thus implying that this parameter is at least, in part, temperature dependent. Sensory thresholds would seem to be reliable reflectors of tissue thyroid status in hypothyroidism, whereas motor responsiveness seems the better guide to thyroid status across the whole spectrum of thyroid function.