PROLACTIN RESPONSES TO THYROTROPHIN RELEASING HORMONE DO NOT DISTINGUISH PATIENTS WITH ISOLATED GONADOTROPHIN DEFICIENCY FROM NORMALS

Authors

  • G. HAWTHORNE,

    1. Metabolic Unit and Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast and Department of Obstetrics and Gynaecology, Queen's University of Belfast, Belfast, Northern Ireland
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  • B. SHERIDAN,

    1. Metabolic Unit and Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast and Department of Obstetrics and Gynaecology, Queen's University of Belfast, Belfast, Northern Ireland
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  • A. I. TRAUB,

    1. Metabolic Unit and Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast and Department of Obstetrics and Gynaecology, Queen's University of Belfast, Belfast, Northern Ireland
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  • A. B. ATKINSON

    Corresponding author
    1. Metabolic Unit and Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast and Department of Obstetrics and Gynaecology, Queen's University of Belfast, Belfast, Northern Ireland
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Dr A. B. Atkinson, Metabolic Unit, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland.

Abstract

Prolactin secretion in response to TRH has been assessed in six patients with isolated gonadotrophin deficiency (IGD) and in eight normal controls. In all six subjects with IGD, serum oestradiol was below the detection limit of the method. There was no statistical difference between either the basal or maximum increment of serum prolactin between the two groups. Recent claims that prolactin responses to TRH distinguish constitutional delay of puberty from IGD have therefore not been supported.

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