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HLA Associations with Hashimoto's thyroiditis

Authors

  • N. Tendon,

    1. Department of Medicine, University of Cambridge Clinical School, Level 5, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
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  • L. Zhang,

    1. Department of Medicine, University of Cambridge Clinical School, Level 5, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
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  • A. P. Weetman

    Corresponding author
    1. Department of Medicine, University of Cambridge Clinical School, Level 5, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
      A. P. Weetman, Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK.
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A. P. Weetman, Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK.

Summary

There Is disagreement over the HLA-DR associations of Hashimoto's (goitrous) thyroiditis. We have studied 86 English Caucasian patients with this condition whose DR types were determined by restriction fragment polymorphism analysis. HLA-DR3 was significantly more frequent In these patients than in 100 controls (χ2= 7·09; P > 0·01). The relative risk was 2·23 and aetiological fraction 0·29. HLA-DPB and DOB alleles were analysed in a proportion of these subjects by enzymatic DNA amplification and oligonucleotide probing. The only significant finding was an excess of HLA-DQw2 (In linkage disequllibrium with DR3) In the Hashimoto group (χ2=7·43, P > 0·007). These results do not support a difference between goitrous and atrophic thyroiditis based on respective associations with HLA-DR5 and DR3, but confirm a recent study in which HLA-DR3 was associated with Hashimoto's thyroiditis. However, It Is possible that genes telomeric to DR3 may be Involved in determining which type of thyroiditis a patient with autoimmune hypothyroidism develops.

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