Correlation between severity of thyroid dysfunction and renal function
Article first published online: 24 MAR 2005
Volume 62, Issue 4, pages 423–427, April 2005
How to Cite
Den Hollander, J. G., Wulkan, R. W., Mantel, M. J. and Berghout, A. (2005), Correlation between severity of thyroid dysfunction and renal function. Clinical Endocrinology, 62: 423–427. doi: 10.1111/j.1365-2265.2005.02236.x
- Issue published online: 24 MAR 2005
- Article first published online: 24 MAR 2005
- (Received 21 September 2004; returned for revision 15 October 2004; finally revised 29 November 2004; accepted 26 January 2005)
Objective Renal function is profoundly influenced by thyroid status; however, this has not been studied in detail in human subjects. The purpose of the present study was to determine the relationship between renal function and thyroid status before and after treatment for hypothyroidism and hyperthyroidism, respectively.
Design and patients In 37 consecutive hypothyroid and 14 hyperthyroid patients renal function as measured by plasma creatinine and glomerular filtration rate (GFR) [based on the modification of diet in renal disease (MDRD) formula] was determined before treatment and after regaining euthyroidism.
Results Renal function improved significantly during treatment of hypothyroidism and decreased during treatment of hyperthyroidism. There was a strong correlation between the change in thyroid status determined as the ratio log10(fT4 post-treatment/fT4 pretreatment) and the change in renal function as a result of therapy expressed as serum creatinine (r2 = 0·81, P < 0·0001) and estimated GFR (0·69, P < 0·0001).
Conclusion The kidney is an important target of thyroid hormone action.