This study was partially supported by a grant of the Italian Minister of Research and University in Rome (no.2003068735).
Age changes the diagnostic accuracy of mean profile and nadir growth hormone levels after oral glucose in postoperative patients with acromegaly
Article first published online: 26 JUN 2006
Volume 65, Issue 2, pages 250–256, August 2006
How to Cite
Colao, A., Pivonello, R., Cavallo, L. M., Gaccione, M., Auriemma, R. S., Esposito, F., Cappabianca, P. and Lombardi, G. (2006), Age changes the diagnostic accuracy of mean profile and nadir growth hormone levels after oral glucose in postoperative patients with acromegaly. Clinical Endocrinology, 65: 250–256. doi: 10.1111/j.1365-2265.2006.02584.x
- Issue published online: 6 JUL 2006
- Article first published online: 26 JUN 2006
- (Received 31 August 2005; returned for revision 18 October 2005; finally revised 24 January 2006; accepted 5 March 2006)
Background This analytical, retrospective study was designed to select cut-off thresholds of mean GH levels during a diurnal profile and nadir GH levels after oral glucose tolerance test (OGTT) according to age to diagnose surgical remission of acromegaly.
Methods One hundred forty-one patients (76 women, aged 44 ± 15 years and 65 men, aged 43 ± 13 years) were included in this study. For the purpose of this study, remission was based on insulin-like growth factor-I (IGF-I) levels in the normal range for age. Diagnostic accuracy was analysed by receiving-operator characteristics (ROC) curves in the entire series, and in young (20–40 years), middle-aged (41–60 years) and older patients (> 60 years), separately.
Results Sixty patients (42·6%) had normal IGF-I levels after surgery. In the entire series, in young and in middle-aged patients, the ROC analysis showed that optimum cut-off for mean GH levels was 2·3 µg/l (diagnostic accuracy range, 94–97%) whereas that for nadir GH after OGTT were, respectively, 0·85, 0·9 and 0·8 µg/l (diagnostic accuracy range, 90–95%). In the older patients, the optimum cut-off selected for mean GH levels was 1·4 µg/l and that for nadir GH after OGTT was 0·5 µg/l (diagnostic accuracy, 100% for both). The comparative analysis of the ROC curves did not show any significant difference between mean GH and nadir GH after OGTT (P = 0·21).
Conclusions The criteria currently accepted for diagnosing post-surgical remission of acromegaly have high diagnostic accuracy only in the patients aged below 60 years. In older patients, lower cut-offs (i.e. = 1·4 µg/l for fasting GH and = 0·5 µg/l for nadir GH after OGTT) predict normal IGF-I levels. Mean GH levels during a diurnal profile have similar diagnostic accuracy of nadir GH levels after OGTT. This suggests that OGTT is not necessary to establish surgical cure.