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References

  • 1
    Zehnder, Y., Luthi, M., Michel, D., Knecht, H., Perrelet, R., Neto, I., Kraenzlin, M., Zach, G. & Lippuner, K. (2004) Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury: a cross-sectional observational study in 100 paraplegic men. Osteoporosis International, 15, 180189.
  • 2
    Maimoun, L., Couret, I., Micallef, J.P., Peruchon, E., Mariano-Goulart, D., Rossi, M., Leroux, J.L. & Ohanna, F. (2002) Use of bone biochemical markers with dual-energy x-ray absorptiometry for early determination of bone loss in persons with spinal cord injury. Metabolism, 51, 958963.
  • 3
    Lazo, M.G., Shirazi, P., Sam, M., Giobbie-Hurder, A., Blacconiere, M.J. & Muppidi, M. (2001) Osteoporosis and risk of fracture in men with spinal cord injury. Spinal Cord, 39, 208214.
  • 4
    Demirel, G., Yilmaz, H., Paker, N. & Onel, S. (1998) Osteoporosis after spinal cord injury. Spinal Cord, 36, 822825.
  • 5
    Garland, D.E., Stewart, C.A., Adkins, R.H., Hu, S.S., Rosen, C., Liotta, F.J. & Weinstein, D.A. (1992) Osteoporosis after spinal cord injury. Journal of Orthopaedic Research, 10, 371378.
  • 6
    Biering-Sorensen, F., Bohr, H. & Schaadt, O. (1988) Bone mineral content of the lumbar spine and lower extremities years after spinal cord lesion. Paraplegia, 26, 293301.
  • 7
    Griffiths, H.J. & Zimmerman, R.E. (1973) The use of photon densitometry to evaluate bone mineral in a group of patients with spinal cord injury. Paraplegia, 10, 279284.
  • 8
    Sabo, D., Blaich, S., Wenz, W., Hohmann, M., Loew, M. & Gerner, H.J. (2001) Osteoporosis in patients with paralysis after spinal cord injury: a cross sectional study in 46 male patients with dual-energy X-ray absorptiometry. Archives of Orthopaedic and Trauma Surgery, 121, 7578.
  • 9
    Warden, S.J., Bennell, K.L., Matthews, B., Brown, D.J., McMeeken, J.M. & Wark, J.D. (2002) Quantitative ultrasound assessment of acute bone loss following spinal cord injury: a longitudinal pilot study. Osteoporosis International, 13, 586592.
  • 10
    Roberts, D., Lee, W., Cuneo, R.C., Wittmann, J., Ward, G., Flatman, R., McWhinney, B. & Hickman, P.E. (1998) Longitudinal study of bone turnover after acute spinal cord injury. Journal of Clinical Endocrinology and Metabolism, 83, 415422.
  • 11
    Slade, J.M., Bickel, C.S., Modlesky, C.M., Majumdar, S. & Dudley, G.A. (2005) Trabecular bone is more deteriorated in spinal cord injured versus estrogen-free postmenopausal women. Osteoporosis International, 16, 263272.
  • 12
    Modlesky, C.M., Majumdar, S., Narasimhan, A. & Dudley, G.A. (2004) Trabecular bone microarchitecture is deteriorated in men with spinal cord injury. Journal of Bone and Mineral Research, 19, 4855.
    Direct Link:
  • 13
    Ragnarsson, K.T. & Sell, G.H. (1981) Lower extremity fractures after spinal cord injury: a retrospective study. Archives of Physical Medicine and Rehabilitation, 62, 418423.
  • 14
    Ingram, R.R., Suman, R.K. & Freeman, P.A. (1989) Lower limb fractures in the chronic spinal cord injured patient. Paraplegia, 27, 133139.
  • 15
    Vestergaard, P., Krogh, K., Rejnmark, L. & Mosekilde, L. (1998) Fracture rates and risk factors for fractures in patients with spinal cord injury. Spinal Cord, 36, 790796.
  • 16
    Comarr, A.E., Hutchinson, R.H. & Bors, E. (1962) Extremity fractures of patients with spinal cord injuries. American Journal of Surgery, 103, 732739.
  • 17
    Kiratli, B.J., Smith, A.E., Nauenberg, T., Kallfelz, C.F. & Perkash, I. (2000) Bone mineral and geometric changes through the femur with immobilization due to spinal cord injury. Journal of Rehabilitation Research and Development, 37, 225233.
  • 18
    Uebelhart, D., Demiaux-Domenech, B., Roth, M. & Chantraine, A. (1995) Bone metabolism in spinal cord injured individuals and in others who have prolonged immobilization: a review. Paraplegia, 33, 669673.
  • 19
    Elefteriou, F. (2005) Neuronal signaling and the regulation of bone remodeling. Cellular and Molecular Life Sciences, 62, 23392349.
  • 20
    Frey-Rindova, P., De Bruin, E.D., Stussi, E., Dambacher, M.A. & Dietz, V. (2000) Bone mineral density in upper and lower extremities during 12 months after spinal cord injury measured by peripheral quantitative computed tomography. Spinal Cord, 38, 2632.
  • 21
    Finsen, V., Indredavik, B. & Fougner, K.J. (1992) Bone mineral and hormone status in paraplegics. Paraplegia, 30, 343347.
  • 22
    Parfitt, A.M. (1994) Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. Journal of Cellular Biochemistry, 55, 273286.
  • 23
    Manolagas, S.C. (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Reviews, 21, 115137.
  • 24
    Zehnder, Y., Risi, S., Michel, D., Knecht, H., Perrelet, R., Kraenzlin, M., Zach, G.A. & Lippuner, K. (2004) Prevention of bone loss in paraplegics over 2 years with alendronate. Journal of Bone and Mineral Research, 19, 10671074.
  • 25
    Pietschmann, P., Pils, P., Woloszczuk, W., Maerk, R., Lessan, D. & Stipicic, J. (1992) Increased serum osteocalcin levels in patients with paraplegia. Paraplegia, 30, 204209.
  • 26
    Demulder, A., Guns, M., Ismail, A., Wilmet, E., Fondu, P. & Bergmann, P. (1998) Increased osteoclast-like cells formation in long-term bone marrow cultures from patients with a spinal cord injury. Calcified Tissue International, 63, 396400.
  • 27
    Lacey, D.L., Timms, E., Tan, H.L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J. & Boyle, W.J. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell, 93, 165176.
  • 28
    Hsu, H., Lacey, D.L., Dunstan, C.R., Solovyev, I., Colombero, A., Timms, E., Tan, H.L., Elliott, G., Kelley, M.J., Sarosi, I., Wang, L., Xia, X.Z., Elliott, R., Chiu, L., Black, T., Scully, S., Capparelli, C., Morony, S., Shimamoto, G., Bass, M.B. & Boyle, W.J. (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proceedings of the National Academy of Sciences of the United States of America, 96, 35403545.
  • 29
    Simonet, W.S., Lacey, D.L., Dunstan, C.R., Kelley, M., Chang, M.S., Luthy, R., Nguyen, H.Q., Wooden, S., Bennett, L., Boone, T., Shimamoto, G., DeRose, M., Elliott, R., Colombero, A., Tan, H.L., Trail, G., Sullivan, J., Davy, E., Bucay, N., Renshaw-Gegg, L., Hughes, T.M., Hill, D., Pattison, W., Campbell, P., Van Sander, S.G., Tarpley, J., Derby, P., Lee, R. & Boyle, W.J. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell, 89, 309319.
  • 30
    Jiang, S.-D., Jiang, L.-S. & Dai, L.-Y. (2006) Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats. Osteoporosis International, in press.
  • 31
    Rogers, M.J., Gordon, S., Benford, H.L., Coxon, F.P., Luckman, S.P., Monkkonen, J. & Frith, J.C. (2000) Cellular and molecular mechanisms of action of bisphosphonates. Cancer, 88, 29612978.
  • 32
    Moran de Brito, C.M., Battistella, L.R., Saito, E.T. & Sakamoto, H. (2005) Effect of alendronate on bone mineral density in spinal cord injury patients: a pilot study. Spinal Cord, 43, 341348.
  • 33
    Hill, E.L., Martin, R.B., Gunther, E., Morey-Holton, E. & Holets, V.R. (1993) Changes in bone in a model of spinal cord injury. Journal of Orthopaedic Research, 11, 537547.
  • 34
    Biering-Sorensen, F., Bohr, H.H. & Schaadt, O.P. (1990) Longitudinal study of bone mineral content in the lumbar spine, the forearm and the lower extremities after spinal cord injury. European Journal of Clinical Investigation, 20, 330335.
  • 35
    Dauty, M., Perrouin Verbe, B., Maugars, Y., Dubois, C. & Mathe, J.F. (2000) Supralesional and sublesional bone mineral density in spinal cord-injured patients. Bone, 27, 305309.
  • 36
    Leblanc, A.D., Schneider, V.S., Evans, H.J., Engelbretson, D.A. & Krebs, J.M. (1990) Bone mineral loss and recovery after 17 weeks of bed rest. Journal of Bone and Mineral Research, 5, 843850.
  • 37
    Inoue, M., Tanaka, H., Moriwake, T., Oka, M., Sekiguchi, C. & Seino, Y. (2000) Altered biochemical markers of bone turnover in humans during 120 days of bed rest. Bone, 26, 281286.
  • 38
    Lueken, S.A., Arnaud, S.B., Taylor, A.K. & Baylink, D.J. (1993) Changes in markers of bone formation and resorption in a bed rest model of weightlessness. Journal of Bone and Mineral Research, 8, 14331438.
  • 39
    Smith, S.M., Nillen, J.L., Leblanc, A., Lipton, A., Demers, L.M., Lane, H.W. & Leach, C.S. (1998) Collagen cross-link excretion during space flight and bed rest. Journal of Clinical Endocrinology and Metabolism, 83, 35843591.
  • 40
    BeDell, K.K., Scremin, A.M., Perell, K.L. & Kunkel, C.F. (1996) Effects of functional electrical stimulation-induced lower extremity cycling on bone density of spinal cord-injured patients. American Journal of Physical Medicine and Rehabilitation, 75, 2934.
  • 41
    Leeds, E.M., Klose, K.J., Ganz, W., Serafini, A. & Green, B.A. (1990) Bone mineral density after bicycle ergometry training. Archives of Physical Medicine and Rehabilitation, 71, 207209.
  • 42
    Pacy, P.J., Hesp, R., Halliday, D.A., Katz, D., Cameron, G. & Reeve, J. (1988) Muscle and bone in paraplegic patients, and the effect of functional electrical stimulation. Clinical Science, 75, 481487.
  • 43
    Jiang, S.D., Jiang, L.S. & Dai, L.Y. (2006) Spinal cord injury causes more damage to bone mass, bone structure, biomechanical properties and bone metabolism than sciatic neurectomy in young rats. Osteoporosis International, 17, 15521561.
  • 44
    Meyers, V.E., Zayzafoon, M., Douglas, J.T. & McDonald, J.M. (2005) RhoA and cytoskeletal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity. Journal of Bone and Mineral Research, 20, 18581866.
  • 45
    Petrtyl, M., Hert, J. & Fiala, P. (1996) Spatial organization of the haversian bone in man. Journal of Biomechanics, 29, 161169.
  • 46
    Doty, S.B. (1981) Morphological evidence of gap junctions between bone cells. Calcified Tissue International, 33, 509512.
  • 47
    Cowin, S.C., Moss-Salentijn, L. & Moss, M.L. (1991) Candidates for the mechanosensory system in bone. Journal of Biomechanical Engineering, 113, 191197.
  • 48
    Palumbo, C., Palazzini, S. & Marotti, G. (1990) Morphological study of intercellular junctions during osteocyte differentiation. Bone, 11, 401406.
  • 49
    Rodan, G.A., Bourret, L.A., Harvey, A. & Mensi, T. (1975) Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodeling. Science, 189, 467469.
  • 50
    Watson, P.A. (1991) Function follows form: generation of intracellular signals by cell deformation. FASEB Journal, 5, 20132019.
  • 51
    Duncan, R.L. & Turner, C.H. (1995) Mechanotransduction and the functional response of bone to mechanical strain. Calcified Tissue International, 57, 344358.
  • 52
    Kondo, H., Nifuji, A., Takeda, S., Ezura, Y., Rittling, S.R., Denhardt, D.T., Nakashima, K., Karsenty, G. & Noda, M. (2005) Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system. Journal of Biological Chemistry, 280, 3019230200.
  • 53
    Giangregorio, L.M., Craven, B.C. & Webber, C.E. (2005) Musculoskeletal changes in women with spinal cord injury: a twin study. Journal of Clinical Densitometry, 8, 347351.
  • 54
    Takata, S. & Yasui, N. (2001) Disuse osteoporosis. Journal of Medical Investigation, 48, 147156.
  • 55
    Claus-Walker, J., Singh, J., Leach, C.S., Hatton, D.V., Hubert, C.W. & Di Ferrante, N. (1977) The urinary excretion of collagen degradation products by quadriplegic patients and during weightlessness. Journal of Bone and Joint Surgery. American Volume, 59, 209212.
  • 56
    Donaldson, C.L., Hulley, S.B., Vogel, J.M., Hattner, R.S., Bayers, J.H. & McMillan, D.E. (1970) Effect of prolonged bed rest on bone mineral. Metabolism, 19, 10711084.
  • 57
    Jones, L.M., Legge, M. & Goulding, A. (2002) Intensive exercise may preserve bone mass of the upper limbs in spinal cord injured males but does not retard demineralisation of the lower body. Spinal Cord, 40, 230235.
  • 58
    Shields, R.K., Dudley-Javoroski, S. & Law, L.A. (2006) Electrically induced muscle contractions influence bone density decline after spinal cord injury. Spine, 31, 548553.
  • 59
    Mohr, T., Podenphant, J., Biering-Sorensen, F., Galbo, H., Thamsborg, G. & Kjaer, M. (1997) Increased bone mineral density after prolonged electrically induced cycle training of paralyzed limbs in spinal cord injured man. Calcified Tissue International, 61, 2225.
  • 60
    Levasseur, R., Sabatier, J.P., Potrel-Burgot, C., Lecoq, B., Creveuil, C. & Marcelli, C. (2003) Sympathetic nervous system as transmitter of mechanical loading in bone. Joint, Bone, Spine, 70, 515519.
  • 61
    Hill, E.L. & Elde, R. (1991) Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell and Tissue Research, 264, 469480.
  • 62
    Hohmann, E.L., Elde, R.P., Rysavy, J.A., Einzig, S. & Gebhard, R.L. (1986) Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers. Science, 232, 868871.
  • 63
    Konttinen, Y., Imai, S. & Suda, A. (1996) Neuropeptides and the puzzle of bone remodeling. State of the art. Acta Orthopaedica Scandinavica, 67, 632639.
  • 64
    Bjurholm, A., Kreicbergs, A., Brodin, E. & Schultzberg, M. (1988) Substance P- and CGRP-immunoreactive nerves in bone. Peptides, 9, 165171.
  • 65
    Bjurholm, A., Kreicbergs, A., Terenius, L., Goldstein, M. & Schultzberg, M. (1988) Neuropeptide Y-, tyrosine hydroxylase- and vasoactive intestinal polypeptide-immunoreactive nerves in bone and surrounding tissues. Journal of the Autonomic Nervous System, 25, 119125.
  • 66
    Calvo, W. & Forteza-Vila, J. (1969) On the development of bone marrow innervation in new-born rats as studied with silver impregnation and electron microscopy. American Journal of Anatomy, 126, 355371.
  • 67
    Duncan, C.P. & Shim, S.S. (1977) J. Edouard Samson Address: the autonomic nerve supply of bone. An experimental study of the intraosseous adrenergic nervi vasorum in the rabbit. Journal of Bone and Joint Surgery. British Volume, 59, 323330.
  • 68
    Hara-Irie, F., Amizuka, N. & Ozawa, H. (1996) Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs. Bone, 18, 2939.
  • 69
    Serre, C.M., Farlay, D., Delmas, P.D. & Chenu, C. (1999) Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers. Bone, 25, 623629.
  • 70
    Goto, T., Yamaza, T., Kido, M.A. & Tanaka, T. (1998) Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone. Cell and Tissue Research, 293, 8793.
  • 71
    Hill, E.L., Turner, R. & Elde, R. (1991) Effects of neonatal sympathectomy and capsaicin treatment on bone remodeling in rats. Neuroscience, 44, 747755.
  • 72
    Sandhu, H.S., Herskovits, M.S. & Singh, I.J. (1987) Effect of surgical sympathectomy on bone remodeling at rat incisor and molar root sockets. Anatomical Record, 219, 3238.
  • 73
    Hukkanen, M., Konttinen, Y.T., Santavirta, S., Paavolainen, P., Gu, X.H., Terenghi, G. & Polak, J.M. (1993) Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience, 54, 969979.
  • 74
    Lundberg, P., Lie, A., Bjurholm, A., Lehenkari, P.P., Horton, M.A., Lerner, U.H. & Ransjo, M. (2000) Vasoactive intestinal peptide regulates osteoclast activity via specific binding sites on both osteoclasts and osteoblasts. Bone, 27, 803810.
  • 75
    Bliziotes, M.M., Eshleman, A.J., Zhang, X.W. & Wiren, K.M. (2001) Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake. Bone, 29, 477486.
  • 76
    Gu, Y. & Publicover, S.J. (2000) Expression of functional metabotropic glutamate receptors in primary cultured rat osteoblasts. Cross-talk with N-methyl-d-aspartate receptors. Journal of Biological Chemistry, 275, 3425234259.
  • 77
    Westbroek, I., Van Der Plas, A., De Rooij, K.E., Klein-Nulend, J. & Nijweide, P.J. (2001) Expression of serotonin receptors in bone. Journal of Biological Chemistry, 276, 2896128968.
  • 78
    Burt-Pichat, B., Lafage-Proust, M.H., Duboeuf, F., Laroche, N., Itzstein, C., Vico, L., Delmas, P.D. & Chenu, C. (2005) Dramatic decrease of innervation density in bone after ovariectomy. Endocrinology, 146, 503510.
  • 79
    White, R.P., Rinaldi, F. & Himwich, H.E. (1956) Central and peripheral nervous effects of atropine sulfate and mepiperphenidol bromide (darstine) on human subjects. Journal of Applied Physiology, 8, 635642.
  • 80
    Munakata, M., Kameyama, J., Kanazawa, M., Nunokawa, T., Moriai, N. & Yoshinaga, K. (1997) Circadian blood pressure rhythm in patients with higher and lower spinal cord injury: simultaneous evaluation of autonomic nervous activity and physical activity. Journal of Hypertension, 15, 17451749.
  • 81
    Schmid, A., Huonker, M., Stahl, F., Barturen, J.M., Konig, D., Heim, M., Lehmann, M. & Keul, J. (1998) Free plasma catecholamines in spinal cord injured persons with different injury levels at rest and during exercise. Journal of the Autonomic Nervous System, 68, 96100.
  • 82
    Krassioukov, A.V., Bunge, R.P., Pucket, W.R. & Bygrave, M.A. (1999) The changes in human spinal sympathetic preganglionic neurons after spinal cord injury. Spinal Cord, 37, 613.
  • 83
    Chantraine, A., Nusgens, B. & Lapiere, C.M. (1986) Bone remodeling during the development of osteoporosis in paraplegia. Calcified Tissue International, 38, 323327.
  • 84
    Minaire, P., Edouard, C., Arlot, M. & Meunier, P.J. (1984) Marrow changes in paraplegic patients. Calcified Tissue International, 36, 338340.
  • 85
    Chantraine, A., Van Ouwenaller, C., Hachen, H.J. & Schinas, P. (1979) Intra-medullary pressure and intra-osseous phlebography in paraplegia. Paraplegia, 17, 391399.
  • 86
    Vaidyanathan, S., Watson, I.D., Jonsson, O., Buczynski, A.Z., Grases, F., Heilberg, I.P., Yasui, T., Wyndaele, J.J., Tozawa, K., Kohri, K., Schurch, B., Hughes, P.L., Singh, G., Soni, B.M., Sett, P. & Fraser, W.D. (2005) Recurrent vesical calculi, hypercalciuria, and biochemical evidence of increased bone resorption in an adult male with paraplegia due to spinal cord injury: is there a role for intermittent oral disodium etidronate therapy for prevention of calcium phosphate bladder stones? Spinal Cord, 43, 269277.
  • 87
    Vaziri, N.D., Pandian, M.R., Segal, J.L., Winer, R.L., Eltorai, I. & Brunnemann, S. (1994) Vitamin D, parathormone, and calcitonin profiles in persons with long-standing spinal cord injury. Archives of Physical Medicine and Rehabilitation, 75, 766769.
  • 88
    Meythaler, J.M., Tuel, S.M. & Cross, L.L. (1993) Successful treatment of immobilization hypercalcaemia using calcitonin and etidronate. Archives of Physical Medicine and Rehabilitation, 74, 316319.
  • 89
    Lamid, S., El Ghatit, A.Z. & Melvin, J.L. (1984) Relationship of hypercalciuria to diet and bladder stone formation in spinal cord injury patients. American Journal of Physical Medicine, 63, 182187.
  • 90
    Kaplan, P.E., Roden, W., Gilbert, E., Richards, L. & Goldschmidt, J.W. (1981) Reduction of hypercalciuria in tetraplegia after weight-bearing and strengthening exercises. Paraplegia, 19, 289293.
  • 91
    Kaplan, P.E., Gandhavadi, B., Richards, L. & Goldschmidt, J. (1978) Calcium balance in paraplegic patients: influence of injury duration and ambulation. Archives of Physical Medicine and Rehabilitation, 59, 447450.
  • 92
    Maynard, F.M. & Imai, K. (1977) Immobilization hypercalcaemia in spinal cord injury. Archives of Physical Medicine and Rehabilitation, 58, 1624.
  • 93
    Zhou, X.J., Vaziri, N.D., Segal, J.L., Winer, R.L., Eltorai, I. & Brunnemann, S.R. (1993) Effects of chronic spinal cord injury and pressure ulcer on 25(OH)-vitamin D levels. Journal of the American Paraplegia Society, 16, 913.
  • 94
    Kohli, A. & Lamid, S. (1986) Risk factors for renal stone formation in patients with spinal cord injury. British Journal of Urology, 58, 588591.
  • 95
    Mechanick, J.I., Pomerantz, F., Flanagan, S., Stein, A., Gordon, W.A. & Ragnarsson, K.T. (1997) Parathyroid hormone suppression in spinal cord injury patients is associated with the degree of neurologic impairment and not the level of injury. Archives of Physical Medicine and Rehabilitation, 78, 692696.
  • 96
    Bauman, W.A., Zhong, Y.G. & Schwartz, E. (1995) Vitamin D deficiency in veterans with chronic spinal cord injury. Metabolism, 44, 16121616.
  • 97
    Bauman, W.A., Morrison, N.G. & Spungen, A.M. (2005) Vitamin D replacement therapy in persons with spinal cord injury. Journal of Spinal Cord Medicine, 28, 203207.
  • 98
    Loomis, W.F. (1967) Skin-pigment regulation of vitamin-D biosynthesis in man. Science, 157, 501506.
  • 99
    Conney, A.H. (1967) Pharmacological implications of microsomal enzyme induction. Pharmacological Reviews, 19, 317366.
  • 100
    Hahn, T.J., Hendin, B.A., Scharp, C.R. & Haddad, J.G. Jr (1972) Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults. New England Journal of Medicine, 287, 900904.
  • 101
    Bauman, W.A., Spungen, A.M., Morrison, N., Zhang, R.L. & Schwartz, E. (2005) Effect of a vitamin D analog on leg bone mineral density in patients with chronic spinal cord injury. Journal of Rehabilitation Research and Development, 42, 625634.
  • 102
    Hicks, T., Hansen, A.P. & Rushing, J.E. (1996) Procedures used by North Carolina dairies for vitamins A and D fortification of milk. Journal of Dairy Science, 79, 329333.
  • 103
    Hock, J.M., Centrella, M. & Canalis, E. (1988) Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology, 122, 254260.
  • 104
    Raisz, L.G. (1988) Local and systemic factors in the pathogenesis of osteoporosis. New England Journal of Medicine, 318, 818828.
  • 105
    Hill, P.A., Tumber, A. & Meikle, M.C. (1997) Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology, 138, 38493858.
  • 106
    Thomas, T., Gori, F., Spelsberg, T.C., Khosla, S., Riggs, B.L. & Conover, C.A. (1999) Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes. Endocrinology, 140, 50365044.
  • 107
    Neuberg, M., Buckbinder, L., Seizinger, B. & Kley, N. (1997) The p53/IGF-1 receptor axis in the regulation of programmed cell death. Endocrine, 7, 107109.
  • 108
    Aksnes, A.K., Hjeltnes, N., Wahlstrom, E.O., Katz, A., Zierath, J.R. & Wallberg-Henriksson, H. (1996) Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients. American Journal of Physiology, 271, E593E600.
  • 109
    Buse, M.G. & Buse, J. (1959) Glucose uptake and response to insulin of the isolated rat diaphragm: the effect of denervation. Diabetes, 8, 218225.
  • 110
    Bauman, W.A., Spungen, A.M., Flanagan, S., Zhong, Y.G., Alexander, L.R. & Tsitouras, P.D. (1994) Blunted growth hormone response to intravenous arginine in subjects with a spinal cord injury. Hormone and Metabolic Research, 26, 152156.
  • 111
    Shetty, K.R., Sutton, C.H., Mattson, D.E. & Rudman, D. (1993) Hyposomatomedinemia in quadriplegic men. American Journal of the Medical Sciences, 305, 95100.
  • 112
    Fowelin, J., Attvall, S., Lager, I. & Bengtsson, B.A. (1993) Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism, 42, 14431447.
  • 113
    Salomon, F., Cuneo, R.C., Hesp, R. & Sonksen, P.H. (1989) The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. New England Journal of Medicine, 321, 17971803.
  • 114
    Camacho-Hubner, C., Woods, K.A., Clark, A.J. & Savage, M.O. (2002) Insulin-like growth factor (IGF)-I gene deletion. Reviews in Endocrine and Metabolic Disorders, 3, 357361.
  • 115
    Dunger, D.B. & Cheetham, T.D. (1996) Growth hormone insulin-like growth factor I axis in insulin-dependent diabetes mellitus. Hormone Research, 46, 26.
  • 116
    Maimoun, L., Lumbroso, S., Paris, F., Couret, I., Peruchon, E., Rouays-Mabit, E., Rossi, M., Leroux, J.L. & Sultan, C. (2006) The role of androgens or growth factors in the bone resorption process in recent spinal cord injured patients: a cross-sectional study. Spinal Cord, March 28 [Epub ahead of print].
  • 117
    Syed, F. & Khosla, S. (2005) Mechanisms of sex steroid effects on bone. Biochemical and Biophysical Research Communications, 328, 688696.
  • 118
    Jilka, R.L., Hangoc, G., Girasole, G., Passeri, G., Williams, D.C., Abrams, J.S., Boyce, B., Broxmeyer, H. & Manolagas, S.C. (1992) Increased osteoclast development after oestrogen loss: mediation by interleukin-6. Science, 257, 8891.
  • 119
    Sun, L., Peng, Y., Sharrow, A.C., Iqbal, J., Zhang, Z., Papachristou, D.J., Zaidi, S., Zhu, L.L., Yaroslavskiy, B.B., Zhou, H., Zallone, A., Sairam, M.R., Kumar, T.R., Bo, W., Braun, J., Cardoso-Landa, L., Schaffler, M.B., Moonga, B.S., Blair, H.C. & Zaidi, M. (2006) FSH directly regulates bone mass. Cell, 125, 247260.
  • 120
    Ducy, P., Schinke, T. & Karsenty, G. (2000) The osteoblast: a sophisticated fibroblast under central surveillance. Science, 289, 15011504.
  • 121
    Schot, L.P. & Schuurs, A.H. (1990) Sex steroids and osteoporosis: effects of deficiencies and substitutive treatments. Journal of Steroid Biochemistry and Molecular Biology, 37, 167182.
  • 122
    Kikuchi, T.A., Skowsky, W.R., El-Toraei, I. & Swerdloff, R. (1976) The pituitary–gonadal axis in spinal cord injury. Fertility and Sterility, 27, 11421145.
  • 123
    Naftchi, N.E., Viau, A.T., Sell, G.H. & Lowman, E.W. (1980) Pituitary–testicular axis dysfunction in spinal cord injury. Archives of Physical Medicine and Rehabilitation, 61, 402405.
  • 124
    Nance, P.W., Shears, A.H., Givner, M.L. & Nance, D.M. (1985) Gonadal regulation in men with flaccid paraplegia. Archives of Physical Medicine and Rehabilitation, 66, 757759.
  • 125
    Tsitouras, P.D., Zhong, Y.G., Spungen, A.M. & Bauman, W.A. (1995) Serum testosterone and growth hormone/insulin-like growth factor-I in adults with spinal cord injury. Hormone and Metabolic Research, 27, 287292.
  • 126
    Maimoun, L., Couret, I., Mariano-Goulart, D., Dupuy, A.M., Micallef, J.P., Peruchon, E., Ohanna, F., Cristol, J.P., Rossi, M. & Leroux, J.L. (2005) Changes in osteoprotegerin/RANKL system, bone mineral density, and bone biochemicals markers in patients with recent spinal cord injury. Calcified Tissue International, 76, 404411.
  • 127
    Rinieris, P., Hatzimanolis, J., Markianos, M. & Stefanis, C. (1989) Effects of treatment with various doses of haloperidol on the pituitary–gonadal axis in male schizophrenic patients. Neuropsychobiology, 22, 146149.
  • 128
    Rinieris, P., Hatzimanolis, J., Markianos, M. & Stefanis, C. (1988) Effects of 4 weeks treatment with chlorpromazine and/or trihexyphenidyl on the pituitary–gonadal axis in male paranoid schizophrenics. European Archives of Psychiatry and Neurological Sciences, 237, 189193.
  • 129
    Brindley, G.S. (1982) Deep scrotal temperature and the effect on it of clothing, air temperature, activity, posture and paraplegia. British Journal of Urology, 54, 4955.
  • 130
    Wang, Y.H., Huang, T.S. & Lien, I.N. (1992) Hormone changes in men with spinal cord injuries. American Journal of Physical Medicine and Rehabilitation, 71, 328332.
  • 131
    Naderi, A.R. & Safarinejad, M.R. (2003) Endocrine profiles and semen quality in spinal cord injured men. Clinical Endocrinology, 58, 177184.
  • 132
    Rosenquist, R.C. (1950) Evaluation of 17-ketosteroid, oestrogen and gonadotrophin excretion in patients with spinal cord injury. American Journal of Medicine, 8, 534535.
  • 133
    Huang, T.S., Wang, Y.H., Lai, J.S., Chang, C.C. & Lien, I.N. (1996) The hypothalamus–pituitary–ovary and hypothalamus–pituitary–thyroid axes in spinal cord-injured women. Metabolism, 45, 718722.
  • 134
    Khong, S., Savic, G., Gardner, B.P. & Ashworth, F. (2005) Hormone replacement therapy in women with spinal cord injury – a survey with literature review. Spinal Cord, 43, 6773.
  • 135
    Steppan, C.M., Crawford, D.T., Chidsey-Frink, K.L., Ke, H. & Swick, A.G. (2000) Leptin is a potent stimulator of bone growth in ob/ob mice. Regulatory Peptides, 92, 7378.
  • 136
    Cornish, J., Callon, K.E., Bava, U., Lin, C., Naot, D., Hill, B.L., Grey, A.B., Broom, N., Myers, D.E., Nicholson, G.C. & Reid, I.R. (2002) Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. Journal of Endocrinology, 175, 405415.
  • 137
    Amling, M., Takeda, S. & Karsenty, G. (2000) A neuro (endo)crine regulation of bone remodeling. Bioessays, 22, 970975.
  • 138
    Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A.F., Beil, F.T., Shen, J., Vinson, C., Rueger, J.M. & Karsenty, G. (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell, 100, 197207.
  • 139
    Karsenty, G. (2001) Leptin controls bone formation through a hypothalamic relay. Recent Progress in Hormone Research, 56, 401415.
  • 140
    Reid, I.R. & Comish, J. (2004) Direct actions of leptin on bone remodeling. Calcified Tissue International, 74, 313316.
  • 141
    Greenway, R.M., Houser, H.B., Lindan, O. & Weir, D.R. (1970) Long-term changes in gross body composition of paraplegic and quadriplegic patients. Paraplegia, 7, 301318.
  • 142
    Sedlock, D.A. & Laventure, S.J. (1990) Body composition and resting energy expenditure in long term spinal cord injury. Paraplegia, 28, 448454.
  • 143
    Hjeltnes, N., De Groot, P., Birkeland, K.I., Falch, J.A. & Iversen, P.O. (2005) Tetraplegic subjects have hyperleptinaemia with marked circadian variation. Clinical Endocrinology, 62, 223227.
  • 144
    Wang, Y.H., Huang, T.S., Liang, H.W., Su, T.C., Chen, S.Y. & Wang, T.D. (2005) Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Archives of Physical Medicine and Rehabilitation, 86, 19641968.
  • 145
    Huang, T.S., Wang, Y.H. & Chen, S.Y. (2000) The relation of serum leptin to body mass index and to serum cortisol in men with spinal cord injury. Archives of Physical Medicine and Rehabilitation, 81, 15821586.
  • 146
    Rayner, D.V. & Trayhurn, P. (2001) Regulation of leptin production: sympathetic nervous system interactions. Journal of Molecular Medicine, 79, 820.
  • 147
    Commins, S.P., Marsh, D.J., Thomas, S.A., Watson, P.M., Padgett, M.A., Palmiter, R. & Gettys, T.W. (1999) Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue. Endocrinology, 140, 47724778.
  • 148
    Sivitz, W.I., Fink, B.D., Morgan, D.A., Fox, J.M., Donohoue, P.A. & Haynes, W.G. (1999) Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats. American Journal of Physiology, 277, E668E677.
  • 149
    Gamstedt, A., Jarnerot, G., Kagedal, B. & Soderholm, B. (1979) Corticosteroids and thyroid function. Different effects on plasma volume, thyroid hormones and thyroid hormone-binding proteins after oral and intravenous administration. Acta Medica Scandinavica, 205, 379383.
  • 150
    Claus-Walker, J., Scurry, M., Carter, R.E. & Campos, R.J. (1977) Steady state hormonal secretion in traumatic quadriplegia. Journal of Clinical Endocrinology and Metabolism, 44, 530535.
  • 151
    Bugaresti, J.M., Tator, C.H., Silverberg, J.D., Szalai, J.P., Malkin, D.G., Malkin, A. & Tay, S.K. (1992) Changes in thyroid hormones, thyroid stimulating hormone and cortisol in acute spinal cord injury. Paraplegia, 30, 401409.
  • 152
    Claus-Walker, J., Vallbona, C., Carter, R.E. & Lipscomb, H.S. (1971) Resting and stimulated endocrine function in human subjects with cervical spinal cord transection. Journal of Chronic Diseases, 24, 193207.
  • 153
    Prakash, V. (1983) Low serum 3,3′,5-triiodothyronine (T3) and reciprocally high serum 3,3′,5′-triiodothyronine (reverse T3) concentration in spinal cord injury patients. Journal of the American Paraplegia Society, 6, 5658.
  • 154
    Prakash, V., Lin, M.S., Song, C.H. & Perkash, I. (1980) Thyroid hypofunction in spinal cord injury patients. Paraplegia, 18, 5663.
  • 155
    Bermudez, F., Surks, M.I. & Oppenheimer, J.H. (1975) High incidence of decreased serum triiodothyronine concentration in patients with nonthyroidal disease. Journal of Clinical Endocrinology and Metabolism, 41, 2740.
  • 156
    Cheville, A.L. & Kirshblum, S.C. (1995) Thyroid hormone changes in chronic spinal cord injury. Journal of Spinal Cord Medicine, 18, 227232.
  • 157
    Mundy, G.R., Shapiro, J.L., Bandelin, J.G., Canalis, E.M. & Raisz, L.G. (1976) Direct stimulation of bone resorption by thyroid hormones. Journal of Clinical Investigation, 58, 529534.
  • 158
    Toh, S.H., Claunch, B.C. & Brown, P.H. (1985) Effect of hyperthyroidism and its treatment on bone mineral content. Archives of Internal Medicine, 145, 883886.
  • 159
    Fraser, S.A., Anderson, J.B., Smith, D.A. & Wilson, G.M. (1971) Osteoporosis and fractures following thyrotoxicosis. Lancet, 1, 981983.
  • 160
    Huang, T.S., Wang, Y.H., Lee, S.H. & Lai, J.S. (1998) Impaired hypothalamus–pituitary–adrenal axis in men with spinal cord injuries. American Journal of Physical Medicine and Rehabilitation, 77, 108112.
  • 161
    Huang, T.S., Wang, Y.H., Chiang, H.S. & Lien, Y.N. (1993) Pituitary–testicular and pituitary–thyroid axes in spinal cord-injured males. Metabolism, 42, 516521.
  • 162
    Zeitzer, J.M., Ayas, N.T., Shea, S.A., Brown, R. & Czeisler, C.A. (2000) Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia. Journal of Clinical Endocrinology and Metabolism, 85, 21892196.
  • 163
    Bacci, V., Schussler, G.C. & Kaplan, T.B. (1982) The relationship between serum triiodothyronine and thyrotropin during systemic illness. Journal of Clinical Endocrinology and Metabolism, 54, 12291235.
  • 164
    Abe, E. & Marians, R.C., Yu, W., Wu, X.B., Ando, T., Li, Y., Iqbal, J., Eldeiry, L., Rajendren, G., Blair, H.C., Davies, T.F. & Zaidi, M. (2003) TSH is a negative regulator of skeletal remodeling. Cell, 115, 151162.
  • 165
    Delany, A.M., Rydziel, S. & Canalis, E. (1996) Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors. Endocrinology, 137, 46654670.
  • 166
    Reid, I.R. (1997) Glucocorticoid osteoporosis – mechanisms and management. European Journal of Endocrinology, 137, 209217.
  • 167
    Subramaniam, M., Colvard, D., Keeting, P.E., Rasmussen, K., Riggs, B.L. & Spelsberg, T.C. (1992) Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto-oncogenes in normal human osteoblast-like cells. Journal of Cellular Biochemistry, 50, 411424.
  • 168
    Ziegler, R. & Kasperk, C. (1998) Glucocorticoid-induced osteoporosis: prevention and treatment. Steroids, 63, 344348.
  • 169
    Grant, J.M. & Yeo, J.D. (1968) Studies on the levels of 17 hydroxy-corticoids in 24-hour specimens of urine from five quadriplegic patients and two paraplegic patients admitted to the Royal North Shore Hospital, Sydney. Paraplegia, 6, 2931.
  • 170
    Culpepper-Morgan, J.A., Twist, D.J., Petrillo, C.R., Soda, K.M. & Kreek, M.J. (1992) beta-Endorphin and cortisol abnormalities in spinal cord-injured individuals. Metabolism, 41, 578581.
  • 171
    Claus-Walker, J.L., Carter, R.E., Lipscomb, H.S. & Vallbona, C. (1969) Analysis of daily rhythms of adrenal function in men with quadriplegia due to spinal cord section. Paraplegia, 6, 195207.
  • 172
    Nicholas, J.J., Streeten, D.H. & Jivoff, L. (1969) A study of pituitary and adrenal function in patients with traumatic injuries of the spinal cord. Journal of Chronic Diseases, 22, 463471.
  • 173
    Eisenstein, A.B., Wenneker, A.S. & Londe, A.M. (1962) Effect of spinal cord transection on adrenocortical function. Proceedings of the Society for Experimental Biology and Medicine, 109, 947950.
  • 174
    Osborn, W., Schoenberg, H.M., Murphy, J.J., Erdman, W.J. & Young, D. (1962) Adrenal function in patients with lesions high in the spinal cord. Journal of Urology, 88, 14.
  • 175
    Hortobagyi, G.N., Theriault, R.L., Porter, L., Blayney, D., Lipton, A., Sinoff, C., Wheeler, H., Simeone, J.F., Seaman, J. & Knight, R.D. (1996) Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group. New England Journal of Medicine, 335, 17851791.
  • 176
    Papapoulos, S.E. (2000) Bisphosphonates in the treatment of osteoporosis. Principles and efficacy. Annales de Medecine Interne, 151, 504510.