Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome
Article first published online: 18 JUL 2007
Volume 68, Issue 1, pages 88–93, January 2008
How to Cite
Giallauria, F., Palomba, S., Manguso, F., Vitelli, A., Maresca, L., Tafuri, D., Lombardi, G., Colao, A., Vigorito, C. and Orio, F. (2008), Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome. Clinical Endocrinology, 68: 88–93. doi: 10.1111/j.1365-2265.2007.03004.x
- Issue published online: 18 JUL 2007
- Article first published online: 18 JUL 2007
- (Received 2 April 2007; returned for revision 22 April 2007; finally revised 24 May 2007; accepted 22 June 2007)
Objective Heart rate recovery (HRR) is a measure derived from exercise test, defined as the fall in heart rate during the first minute after maximal exercise. Abnormal HRR is a measure of autonomic dysfunction associated with an increased mortality. This study was performed to evaluate the HRR in polycystic ovary syndrome (PCOS).
Design Prospective controlled clinical study.
Patients Seventy-five PCOS women compared to 75 healthy women matched for age (21·7 ± 2·1 years vs. 21·9 ± 1·8 years, respectively) and body mass index (BMI) (29·0 ± 2·6 kg/m2 vs. 29·1 ± 2·9 kg/m2, respectively).
Measurements Subjects were studied for their hormonal and metabolic profile, and underwent cardiopulmonary exercise test (CPX).
Results PCOS women showed a significantly reduced HRR (12·9 ± 1·8 vs. 20·4 ± 3·1 beats/min, P < 0·001) compared to healthy controls, an impairment in maximal oxygen consumption (18·0 ± 2·3 ml/kg/min vs. 29·3 ± 3·9 ml/kg/min) and in oxygen consumption at anaerobic threshold (13·6 ± 2·6 ml/kg/min vs. 24·2 ± 3·0 ml/kg/min). In PCOS women, abnormal HRR was inversely correlated to BMI (r = −0·582, P < 0·001) and to the area under the curve for insulin (r = −0·596, P < 0·001).
Conclusions Our data demonstrate an abnormal HRR after maximal CPX in young overweight PCOS patients, and that HRR should be investigated as a further potential marker of increased cardiovascular risk in PCOS.