Both authors contributed equally to this work.
Predictors of anterior pituitary insufficiency after traumatic brain injury
Article first published online: 30 JUL 2007
© 2007 The Authors
Volume 68, Issue 2, pages 206–212, February 2008
How to Cite
Schneider, M., Schneider, H. J., Yassouridis, A., Saller, B., Von Rosen, F. and Stalla, G. K. (2008), Predictors of anterior pituitary insufficiency after traumatic brain injury. Clinical Endocrinology, 68: 206–212. doi: 10.1111/j.1365-2265.2007.03020.x
- Issue published online: 30 JUL 2007
- Article first published online: 30 JUL 2007
- (Received 27 April 2007; returned for revision 14 June 2007; finally revised 9 July 2007; accepted 11 July 2007)
Background Several studies have reported a high prevalence of hypopituitarism after traumatic brain injury (TBI). Risk stratification is a prerequisite for cost-effective hormonal screening of these patients. However, it is still unclear which risk factors predispose patients to develop anterior hypopituitarism after TBI.
Objective To assess clinical and radiological risk factors for post-traumatic hypopituitarism.
Patients and methods Seventy-eight consecutive patients (52 men, 26 women; mean age 36·0 years, range 18–65 years) with mild, moderate or severe TBI were studied. Endocrine and clinical parameters were assessed 3 and 12 months after TBI.
Results We found diffuse axonal injury, basal skull fracture and older age to be major risk factors of post-traumatic hypopituitarism.
Conclusions We have defined specific risk factors for the development of post-traumatic hypopituitarism that are consistent with pathophysiological considerations. These findings might help to identify at-risk patients.