Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children
Article first published online: 3 SEP 2007
© 2007 The Authors
Volume 68, Issue 3, pages 416–422, March 2008
How to Cite
Kim, H. J., Lee, S., Kim, T. W., Kim, H. H., Jeon, T. Y., Yoon, Y. S., Oh, S. W., Kwak, H. and Lee, J. G. (2008), Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children. Clinical Endocrinology, 68: 416–422. doi: 10.1111/j.1365-2265.2007.03058.x
- Issue published online: 3 SEP 2007
- Article first published online: 3 SEP 2007
- (Received 7 March 2007; returned for revision 13 April 2007; finally revised 14 June 2007; accepted 28 August 2007)
Objective Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise with changes in ghrelin.
Design A prospective randomized study.
Patients and measurements We randomized 17 overweight volunteers (11-year-old boys) to a 12-week combined exercise group (EG, n = 8) or control group (CG, n = 9). At baseline, 1, 4 and 12 weeks, we measured body weight and composition, insulin, leptin, total ghrelin and acylated ghrelin.
Results Compared with the CG, body weight, percentage body fat and homeostatic model assessment (HOMA) indices were significantly lower throughout the 12 weeks in the EG. Total ghrelin and UAG levels gradually increased to 131·9 ± 5·2% and 130·4 ± 5·2% of baseline, respectively, at week 12 in the EG, whereas AG concentration remained unchanged throughout the 12 weeks both within each group and between the groups. At week 12, there were differences in the total ghrelin level and UAG level between the groups.
Conclusions This study shows an increase in unacylated acylated ghrelin and unchanged acylated ghrelin after a 12-week combined exercise programme in overweight children. These findings provide evidence of favourable effects of exercise on improving energy metabolism.