Previous radiotherapy negatively influences quality of life during 4 years of follow-up in patients cured from acromegaly
Article first published online: 28 JUN 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Volume 69, Issue 1, pages 123–128, July 2008
How to Cite
Van Der Klaauw, A. A., Biermasz, N. R., Hoftijzer, H. C., Pereira, A. M. and Romijn, J. A. (2008), Previous radiotherapy negatively influences quality of life during 4 years of follow-up in patients cured from acromegaly. Clinical Endocrinology, 69: 123–128. doi: 10.1111/j.1365-2265.2007.03169.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- (Received 6 November 2007; returned for revision 18 November 2007; finally revised 11 December 2007; accepted 11 December 2007)
Objective Cross-sectional studies have shown impaired quality of life (QoL) in patients in biochemical control of acromegaly. The aim of this study was to assess longitudinal changes in QoL in a homogenous cohort of patients with sustained biochemical control of acromegaly.
Design Prospective follow-up study.
Patients and methods QoL was assessed using four health-related QoL questionnaires (HADS, Hospital Anxiety and Depression Scale; MFI-20, Multidimensional Fatigue Index; NHP, Nottingham Health Profile; and SF-36, Short Form-36) and one disease-specific acromegaly quality of life (ACRO-QOL) questionnaire in 82 patients (43 men) with strict biochemical control of acromegaly, aged 56 years (range 29–84 years) at baseline and after 4 years of follow-up. The mean duration of controlled disease was 12 years (range 1–26 years).
Results During follow-up, scores in 5 of 26 QoL subscales significantly worsened: physical and social functioning (SF-36), physical fatigue (MFI-20), and psychological well-being and personal relations (ACRO-QOL). Using linear regression analysis, baseline item scores predicted the follow-up scores, indicating individual stability over time. Previous radiotherapy (n = 27, 33%) negatively influenced several QoL subscales at follow-up: energy, pain and social isolation (NHP), physical fatigue and reduction in activity and motivation (MFI-20), depression and total anxiety and depression scores (HADS) and physical performance (ACRO-QOL).
Conclusion During 4 years of follow-up in patients with long-term biochemical control of ACRO-QOL is subtly, but progressively impaired. Radiotherapy was the predominant indicator of progressive impairment in QoL.