Daham Kim and Kwang Joon Kim have contributed equally to this work.
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ORIGINAL ARTICLE
The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function
Article first published online: 5 OCT 2012
DOI: 10.1111/j.1365-2265.2011.04312.x
© 2011 Blackwell Publishing Ltd
Additional Information
How to Cite
Kim, D., Kim, K. J., Huh, J. H., Lee, B.-W., Kang, E. S., Cha, B. S. and Lee, H. C. (2012), The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function. Clinical Endocrinology, 77: 679–683. doi: 10.1111/j.1365-2265.2011.04312.x
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Daham Kim and Kwang Joon Kim have contributed equally to this work.
Publication History
- Issue published online: 5 OCT 2012
- Article first published online: 5 OCT 2012
- Accepted manuscript online: 9 DEC 2011 12:06PM EST
- (Received 27 September 2011; returned for revision 27 October 2011; finally revised 21 November 2011; accepted 5 December 2011)
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Summary
Objective Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test.
Design A clinical, retrospective study.
Patients and measurements A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined.
Results The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI.
Conclusions The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.