Thyroid function and prevalent and incident metabolic syndrome in older adults: the health, ageing and body composition study
Article first published online: 23 APR 2012
© 2011 Blackwell Publishing Ltd
Volume 76, Issue 6, pages 911–918, June 2012
How to Cite
Waring, A. C., Rodondi, N., Harrison, S., Kanaya, A. M., Simonsick, E. M., Miljkovic, I., Satterfield, S., Newman, A. B., Bauer, D. C. and for the Health, Ageing, and Body Composition (Health ABC) Study (2012), Thyroid function and prevalent and incident metabolic syndrome in older adults: the health, ageing and body composition study. Clinical Endocrinology, 76: 911–918. doi: 10.1111/j.1365-2265.2011.04328.x
- Issue published online: 23 APR 2012
- Article first published online: 23 APR 2012
- Accepted manuscript online: 20 DEC 2011 01:05PM EST
- (Received 20 September 2011; returned for revision 12 October 2011; finally revised 30 November 2011; accepted 14 December 2011)
Objective Both subclinical hypothyroidism and the metabolic syndrome have been associated with increased risk of coronary heart disease events. It is unknown whether the prevalence and incidence of metabolic syndrome is higher as TSH levels increase, or in individuals with subclinical hypothyroidism. We sought to determine the association between thyroid function and the prevalence and incidence of the metabolic syndrome in a cohort of older adults.
Design Data were analysed from the Health, Ageing and Body Composition Study, a prospective cohort of 3075 community-dwelling US adults.
Participants Two thousand one hundred and nineteen participants with measured TSH and data on metabolic syndrome components were included in the analysis.
Measurements TSH was measured by immunoassay. Metabolic syndrome was defined per revised ATP III criteria.
Results At baseline, 684 participants met criteria for metabolic syndrome. At 6-year follow-up, incident metabolic syndrome developed in 239 individuals. In fully adjusted models, each unit increase in TSH was associated with a 3% increase in the odds of prevalent metabolic syndrome (OR, 1·03; 95% CI, 1·01–1·06; P = 0·02), and the association was stronger for TSH within the normal range (OR, 1·16; 95% CI, 1·03–1·30; P = 0·02). Subclinical hypothyroidism with a TSH > 10 mIU/l was significantly associated with increased odds of prevalent metabolic syndrome (OR, 2·3; 95% CI, 1·0–5·0; P = 0·04); the odds of incident MetS was similar (OR 2·2), but the confidence interval was wide (0·6–7·5).
Conclusions Higher TSH levels and subclinical hypothyroidism with a TSH > 10 mIU/l are associated with increased odds of prevalent but not incident metabolic syndrome.