Original Article

Low-grade systemic inflammation and suboptimal bone mineral density throughout adolescence: a prospective study in girls

  1. Raquel Lucas1,2,3,*,
  2. Elisabete Ramos1,2,3,
  3. Andreia Oliveira1,2,3,
  4. Teresa Monjardino1,2,3,
  5. Henrique Barros1,2,3

Article first published online: 5 OCT 2012

DOI: 10.1111/j.1365-2265.2012.04430.x

Issue

Clinical Endocrinology

Clinical Endocrinology

Volume 77, Issue 5, pages 665–671, November 2012

Additional Information

How to Cite

Lucas, R., Ramos, E., Oliveira, A., Monjardino, T. and Barros, H. (2012), Low-grade systemic inflammation and suboptimal bone mineral density throughout adolescence: a prospective study in girls. Clinical Endocrinology, 77: 665–671. doi: 10.1111/j.1365-2265.2012.04430.x

Author Information

  1. 1

    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal

  2. 2

    Institute of Public Health, University of Porto, Porto, Portugal

  3. 3

    Cardiovascular R&D Unit, University of Porto Medical School, Porto, Portugal

* Correspondence: Raquel Lucas, Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Alameda Prof. Hernâni Monteiro, 4200 319 Porto, Portugal, Tel.: +351 22 551 36 52; Fax: +351 22 551 36 53;
E-mail: rlucas@med.up.pt

Publication History

  1. Issue published online: 5 OCT 2012
  2. Article first published online: 5 OCT 2012
  3. Accepted manuscript online: 10 MAY 2012 07:01AM EST
  4. Manuscript Accepted: 26 APR 2012
  5. Manuscript Revised: 17 APR 2012
  6. Manuscript Revised: 29 MAR 2012
  7. Manuscript Received: 6 MAR 2012

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Summary

Objective

We aimed at quantifying the associations between high-sensitivity C-reactive protein (hs-CRP) and forearm bone mineral density (BMD) throughout adolescence in overweight and normal-weight girls.

Design

Prospective cohort study.

Patients

346 girls born in 1990 and attending schools in Porto, Portugal.

Measurements

Adolescents were evaluated at 13 and 17 years of age using a standard protocol. Forearm BMD was measured by dual-energy X-ray absorptiometry. Anthropometric assessment included weight, height, body fat percentage and waist circumference. Girls were categorized according to age- and sex-specific body mass index (BMI) percentiles as normal weight in both evaluations or overweight in at least one assessment. Pubertal development was estimated using menarche age. Serum hs-CRP was determined using particle-enhanced immunonephelometry. Hs-CRP was log-transformed, and associations were quantified using linear regression coefficients and 95% confidence intervals (95%CI).

Results

An inverse association between hs-CRP and BMD was observed from 13 years of age in overweight girls [−11·26 mg/cm2 (−21·99, −0·52)]. Among normal-weight adolescents, 13-year-old hs-CRP was negatively associated with prospective BMD variation between 13 and 17 years of age [−1·90 mg/cm2 year (−3·35, −0·45)]. Overweight girls who maintained higher levels of hs-CRP throughout adolescence had lower 17-year-old BMD (adjusted mean 0·441 vs 0·483 g/cm2 in those who remained with lower levels of hs-CRP). At 17 years of age, significant inverse associations were found between hs-CRP and BMD among normal-weight and overweight girls.

Conclusions

Obesity-related early systemic inflammation might be involved in suboptimal bone accrual, particularly in overweight girls.

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