Pregnancy-associated plasma protein-A is related to gender and to adipocytokine levels: results of The Health Survey of Catalonia

Authors

  • Clara Joaquín,

    Corresponding author
    • Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Maria L. Granada,

    1. Hormone and Biochemical Laboratory, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Cruz Pastor,

    1. Hormone and Biochemical Laboratory, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Conxa Castell,

    1. Agència de Salut Pública, Generalitat de Catalunya, Badalona, Barcelona, Spain
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  • Rocío Puig,

    1. Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Núria Alonso,

    1. Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Enric Serra,

    1. Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Anna Sanmartí,

    1. Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Marius Foz,

    1. Department of Internal Medicine, Department of Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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  • Manel Puig-Domingo

    1. Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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Correspondence: Clara Joaquín, Hospital Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Barcelona, Spain. Tel.: +34 934 978 860; Fax: +34 934 978 497; E-mail: clara.joaquim@gmail.com

Summary

Objective

Pregnancy-associated plasma protein-A (PAPP-A) is a protease promoting IGF1 tissue availability and considered as a new biomarker of cardiovascular disease.

Aim

To evaluate the relationship between PAPP-A concentrations and anthropometric variables, physical activity, smoking status, glucose homoeostasis and adipocytokines in healthy adults.

Design and methods

One hundred and forty-nine subjects (77 women; mean age 39·7 ± 14 years; mean BMI 23·7 ± 1·9 kg/m2) were randomly selected from 8000 adults of The Health Survey of Catalonia. Possible effects of gender, age, body composition, smoking status, physical activity, glucose homoeostasis and adipocytokines on PAPP-A concentrations were assessed.

Results

Pregnancy-associated plasma protein-A was significantly higher in men than in women [ 1·04 (0·61–0·44) vs 0·61 (0·41–0·90) μIU/ml; < 0·0001]; there were no differences in relation to physical activity or smoking status. PAPP-A showed a negative correlation with leptin in men (P = 0·01) and women (P = 0·05), and a positive correlation with adiponectin (P = 0·006) in women and a trend (P = 0·073) in men. Homoeostasis model assessment of insulin resistance (HOMA-IR) showed a negative correlation with PAPP-A only in women (P = 0·019). No association was found with blood pressure, IGF1, lipids or glucose in either gender. When a multiple regression analysis was performed including gender, age, BMI, waist-hip ratio, HOMA-IR, adiponectin and leptin as confounders, PAPP-A was independently correlated with adiponectin (β = 0·23; P = 0·02) and leptin (β = −0·33; P = 0·04).

Conclusions

Our study shows a sexual dimorphism of PAPP-A, and a possible influence of leptin and adiponectin on its concentrations in healthy subjects. The mechanisms responsible for this relationship remain to be determined.

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