Presented in part at 14th International Congress of Cytology, May 2001, Amsterdam, The Netherlands.
Benign mucocele-like lesion of the breast: how to differentiate from mucinous carcinoma before surgery
Article first published online: 25 MAR 2004
Volume 15, Issue 2, pages 104–108, April 2004
How to Cite
Cheng, L., Lee, W.-Y. and Chang, T.-W. (2004), Benign mucocele-like lesion of the breast: how to differentiate from mucinous carcinoma before surgery. Cytopathology, 15: 104–108. doi: 10.1111/j.1365-2303.2004.00130.x
- Issue published online: 25 MAR 2004
- Article first published online: 25 MAR 2004
- Accepted for publication 15 January 2004
- mucocele-like lesion;
- mucinous carcinoma;
- breast neoplasm;
- atypical ductal hyperplasia;
The aim of the study was to improve the pre-operative diagnosis of mammary mucinous lesions. All mucinous lesions detected by fine needle aspiration (FNA) and confirmed by histological examination were reviewed by cytological findings, mammographic appearances and sonographic findings. Twenty aspirates had corresponding pathology, including 12 mucinous carcinomas, two mucocele-like lesions (MLL) with atypical ductal hyperplasia, three MLL with ductal hyperplasia and three simple MLL. Simple MLL and mucocele-like with ductal hyperplasia showed scant cellularity, no or rare intact single tumour cells, monolayered arrangement and absence of nuclear atypia. In contrast, most mucinous carcinomas showed higher cellularity, more single tumour cells, three-dimensional clusters, and mild to marked nuclear atypia. However, MLL with atypical ductal hyperplasia showed cytological features overlapping with mucinous carcinoma. MLL had a non-specific mammographic appearance and showed a cystic lesion on sonography. Mucinous carcinoma appeared as a solid mass on sonography and as a distinct nodule on mammography. Based on the combination of FNA cytology and image findings, benign MLL can be correctly distinguished from mucinous carcinoma before surgery.