Transbronchial fine needle aspiration cytology in the diagnosis of mediastinal/hilar sarcoidosis
Article first published online: 6 DEC 2006
Volume 18, Issue 1, pages 3–7, February 2007
How to Cite
Smojver-Ježek, S., Peroš-Golubičić, T., Tekavec-Trkanjec, J., Mažuranić, I. and Alilović, M. (2007), Transbronchial fine needle aspiration cytology in the diagnosis of mediastinal/hilar sarcoidosis. Cytopathology, 18: 3–7. doi: 10.1111/j.1365-2303.2006.00336.x
- Issue published online: 23 JAN 2007
- Article first published online: 6 DEC 2006
- Accepted for publication 13 December 2005
- fine needle aspiration cytology;
- mediastinal/hilar lymphadenopathy;
- diagnostic accuracy
Objective: The diagnostic value of transbronchial/transtracheal fine needle aspiration (TBFNA) cytology in the patients with mediastinal and/or hilar lymphadenopathy has been investigated.
Method: Out of 116 patients with mediastinal/hilar lymphadenopathy, the diagnosis of sarcoidosis was established in 88 (75.9%). One hundred and seventy-one TBFNAs from different lymph node stations were performed using a cytological 26-gauge needle. Adequate lymph node samples were obtained in 157 of 171 (91.8%) TBFNA and 14 of 171 (8.2%) TBFNA samples were inadequate.
Results: Cytological findings consistent with sarcoidosis were found in 79 of 88 (89.77%) patients and 133 of 157 (84.71%) samples. The sensitivity of TBFNA cytology in sarcoidosis presenting as mediastinal/hilar lymphadenopathy was 78.7%, specificity 92.3%.
Conclusions: Overall diagnostic accuracy of TBFNA cytology in the diagnosis of sarcoidosis was 86.2%, and cytological findings consistent with sarcoidosis were the only morphological diagnosis of sarcoidosis in 63.6% of patients.