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Usefulness of oral cytopathology in the diagnosis of infectious diseases

Authors

  • P. H. Braz-Silva,

    1. Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, University of Nice Sophia Antipolis, Nice, France
    2. Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil
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  • M. H. C. G. Magalhães,

    1. Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil
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  • V. Hofman,

    1. Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, University of Nice Sophia Antipolis, Nice, France
    2. Inserm ERI-21/EA 4319, Faculty of Medicine, University of Nice Sophia Antipolis, Nice, France
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  • K. L. Ortega,

    1. Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil
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  • M. I. Ilie,

    1. Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, University of Nice Sophia Antipolis, Nice, France
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  • G. Odin,

    1. Department of Oto-Rhino-Laryngology, Pasteur Hospital, Nice, France
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  • P. Vielh,

    1. Department of Pathology, Gustave Roussy Institute, Villejuif, France
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  • P. Hofman

    1. Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, University of Nice Sophia Antipolis, Nice, France
    2. Inserm ERI-21/EA 4319, Faculty of Medicine, University of Nice Sophia Antipolis, Nice, France
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P. Hofman, INSERM ERI-21/4319, Faculté de Médecine, avenue de Valombrose, 06107 Nice, Cedex 01, France
Tel.: +33 4 92 03 88 55; Fax: +33 4 92 03 88 50;
E-mail: hofman.p@chu-nice.fr

Abstract

P. H. Braz-Silva, M. H. C. G. Magalhães, V. Hofman, K. L. Ortega, M. I. Ilie, G. Odin, P. Vielh and P. Hofman

Usefulness of oral cytopathology in the diagnosis of infectious diseases

In recent years, the incidence of oral opportunistic infections has increased, partly due to the widespread implementation of organ and bone marrow transplantation and the increase in the prevalence of human immunodeficiency virus (HIV) infection. Cytology can be used as a rapid, inexpensive and simple routine procedure in diagnosing infectious diseases of the mouth. Moreover, ancillary methods can be applied to cytological samples, increasing the specificity and sensitivity for the diagnosis of infectious diseases. This review describes the cytopathological features of the main viral, fungal, bacterial and parasitic infections of the mouth. Cytological techniques of specimen collection, identification of infectious agents by cytomorphological approaches and ancillary methods, and diagnostic pitfalls will be discussed.

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