The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat
Article first published online: 20 MAR 2008
European Journal of Clinical Investigation
Volume 13, Issue 3, pages 215–220, June 1983
How to Cite
HOLMIN, T., AGARDH, C.-D., ALINDER, G., HERLIN, P. and HULTBERG, B. (1983), The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat. European Journal of Clinical Investigation, 13: 215–220. doi: 10.1111/j.1365-2362.1983.tb00090.x
- Issue published online: 20 MAR 2008
- Article first published online: 20 MAR 2008
- Received 10 February 1982 and in revised form 10 December 1982
- labile phosphates;
- amino acids;
Abstract. The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy.
The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state.