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Effect of calcium intake on serum levels of 25-hydroxyvitamin D3
Article first published online: 20 MAR 2008
DOI: 10.1111/j.1365-2362.1988.tb01165.x
1365-2362/asset/cover.gif?v=1&s=1707dc38635ea38d7a68981f9cee3db380a484e5 "European Journal of Clinical Investigation")
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How to Cite
BERLIN, T. and BJÖRKHEM, I. (1988), Effect of calcium intake on serum levels of 25-hydroxyvitamin D3. European Journal of Clinical Investigation, 18: 52–55. doi: 10.1111/j.1365-2362.1988.tb01165.x
Publication History
- Issue published online: 20 MAR 2008
- Article first published online: 20 MAR 2008
- Received 13 May 1987 and in revised form 11 August 1987
- Abstract
- References
- Cited By
Keywords:
- Calcium 1,25-dihydroxyvitamin D;
- human;
- 25-hydroxyvitamin D3;
- rat
Abstract. The effects of high calcium intake on vitamin D metabolism were investigated. To the normal diet of 14 healthy men, 2 g calcium were added daily for 6–7 weeks. The mean serum concentration of 25-hydroxyvitamin D3 increased from 73 ± 7 to 94 ± 6 nmol l-1 (P<0·05, Student's unpaired t-test; P<0·01, paired t-test) in the subjects receiving calcium, whereas there was only a minimal increase, from 67 ± 5 to 71 ± 4 nmol l-1 in a control group on a normal diet. At the end of the study the difference between the test group and the controls was highly significant (P<0·005). The calcium loading caused a statistically significant depression of the serum levels of 1,25-dihydroxyvitamin D. The results obtained are in agreement with previous studies in rats and indicate that calcium intake is of some importance for the serum level of 25-hydroxyvitamin D3. The findings are discussed in relation to our previous finding that there is a relationship between high 25-hydroxyvitamin D3 levels and hypercalciuria in renal-stone formers.