Human CD5-positive B Cells in lymphoid malignancy and connective tissue diseases

  1. P. YOUINOU1,*,
  2. L. E. MACKENZIE2,
  3. A. LAMOUR1,
  4. R. A. MAGEED3,
  5. P. M. LYDYARD2

Article first published online: 20 MAR 2008

DOI: 10.1111/j.1365-2362.1993.tb00753.x

Issue

European Journal of Clinical Investigation

European Journal of Clinical Investigation

Volume 23, Issue 3, pages 139–150, March 1993

Additional Information

How to Cite

YOUINOU, P., MACKENZIE, L. E., LAMOUR, A., MAGEED, R. A. and LYDYARD, P. M. (1993), Human CD5-positive B Cells in lymphoid malignancy and connective tissue diseases. European Journal of Clinical Investigation, 23: 139–150. doi: 10.1111/j.1365-2362.1993.tb00753.x

Author Information

  1. 1

    *Laboratory of Immunology, Brest University Medical School Hospital, Brest, France

  2. 2

    †Department of Immunology, University College and Middlesex School of Medicine, London, UK

  3. 3

    ‡The Kennedy Institute of Rheumatology, London, UK

* Laboratory of Immunology, Brest University Medical School Hospital, BP 824 F-29609 Brest Cédex, France.

Publication History

  1. Issue published online: 20 MAR 2008
  2. Article first published online: 20 MAR 2008
  3. Received 10 August 1992 and in revised form 25 November 1992; accepted 3 December 1992

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Keywords:

  • Auto-immunity;
  • CD5-positive B cells;
  • lymphoid malignancy;
  • rheumatoid arthritis;
  • Sjogren's syndrome

Abstract. The current literature on human CD5-positive B cells (CD5 + B cells) has been analysed, with a special emphasis on non organ-specific auto-immune diseases. Malignant cells of most of the chronic lymphoid leukaemias of the B cell lineage express the CD5 molecule. Antibodies of the IgM class produced by leukaemic B cells are multispecific auto-antibodies. The CD5 + B cell subset may be expanded in non organ-specific autoimmune diseases, such as rheumatoid arthritis, primary Sjogren's syndrome, systemic lupus erythematosus. This holds true for various conditions, including organ-specific auto-immune diseases. Since auto-immune features are common in lymphoproliferative disorders, and the latter be a complication in non organ-specific auto-immune diseases, CD5 + B cells may represent an intermediatary between these auto-immune diseases and B cell lym-phoproliferations. Studies on the regulation of CDS + B cell production and function are likely to shed light on the aetiology of, and pathogenetic mechanisms operating in the different disease states.

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