Department of Internal Medicine, Krankenhaus der Barmherzigen Brüder, Teaching, Hospital Karl Franzens University Graz (D. Weber-Mzell, P. Kotanko); Department of Pediatrics (A. C. Hauer, U. Goriup, N. Lanner, I. A. Ahmaida, S. Haitchi-Petnehazy, J. Deutsch), Department of Gynecology Obstetrics (J. Haas), Institute of Laboratory Medicine (W. Erwa), and Department of Blood Group Serology and Hematotherapy (G. Lanzer), University Hospital Graz; Militärkommando Steiermark (M. Stenzel), Graz, Austria.
Gender, age and seasonal effects on IgA deficiency: a study of 7293 Caucasians
Article first published online: 15 MAR 2004
European Journal of Clinical Investigation
Volume 34, Issue 3, pages 224–228, March 2004
How to Cite
Weber-Mzell, D., Kotanko, P., Hauer, A. C., Goriup, U., Haas, J., Lanner, N., Erwa, W., Ahmaida, I. A., Haitchi-Petnehazy, S., Stenzel, M., Lanzer, G. and Deutsch, J. (2004), Gender, age and seasonal effects on IgA deficiency: a study of 7293 Caucasians. European Journal of Clinical Investigation, 34: 224–228. doi: 10.1111/j.1365-2362.2004.01311.x
- Issue published online: 15 MAR 2004
- Article first published online: 15 MAR 2004
- Received 30 July 2003; accepted 7 November 2003
- Age- and gender-related variability;
- immunoglobulin A;
- seasonal variability;
- serum IgA deficiency
Background The frequency of serum IgA deficiency (SIgAD) differs between populations. We examined the prevalence of SIgAD in healthy Caucasians.
Materials and methods Serum immunoglobulin A (SIgA) was measured in 7293 volunteers (2264 women, 5029 men) aged 30 ± 14·2 years (mean ± SD; range: 12–66). Serum immunoglobulin A and subnormal SIgA levels were defined by a SIgA level < 0·07 g L−1, and between 0·07 and 0·7 g L−1, respectively. Means were compared by analysis of variance (anova) and analysis of covariance (ancova); frequencies by the χ2 test.
Results Fifteen subjects (0·21%; one woman, 14 men) had SIgAD. Subnormal SIgA levels were found in 155 persons (2·13%): 21 females (0·93% of the females) and 134 males (2·66% of the males; difference: 1·74%; 95% CI: 1·12–2·33%; P < 0·001). Males were more likely to have subnormal SIgA levels or SIgAD (odds ratio 3·09, 95% CI: 1·97–4·85). The prevalence of SIgAD and subnormal SIgA was lowest in winter (χ2 = 14·8; P = 0·002; 3 d.f.; and χ2 = 43·2; P < 0·001; 3 d.f., respectively).
Serum immunoglobulin A concentrations were significantly higher during winter. Serum immunoglobulin A levels increased with age on average by 0·2 ± 0·06 g L−1 per decade of life (P < 0·001). Taking into account the influence of age, SIgA concentration was lower in females as compared with males.
Conclusion The prevalence of SIgAD and subnormal SIgA levels is increased in males. There exists a significant influence of gender, age and seasons on SIgA levels.