Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht (M. J. C. A. van Trijp, Y. T. van der Schouw, M. Muller, D. E. Grobbee, M. L. Bots); Department of Internal Medicine, St. Antonius Hospital, Nieuwegein (W. J. W. Bos), the Netherlands.
Alcohol and arterial wave reflections in middle aged and elderly men
Version of Record online: 22 SEP 2005
European Journal of Clinical Investigation
Volume 35, Issue 10, pages 615–621, October 2005
How to Cite
Van Trijp, M. J. C. A., Bos, W. J. W., Van Der Schouw, Y. T., Muller, M., Grobbee, D. E. and Bots, M. L. (2005), Alcohol and arterial wave reflections in middle aged and elderly men. European Journal of Clinical Investigation, 35: 615–621. doi: 10.1111/j.1365-2362.2005.01560.x
- Issue online: 22 SEP 2005
- Version of Record online: 22 SEP 2005
- Received 29 June 2005; accepted 19 August 2005
- arterial wave reflections;
- augmentation index;
Background Augmentation index (AIx) is a measure of arterial wave reflection, providing information on the workload of the heart. and is a possible marker for cardiovascular disease risk. The relation of alcohol consumption with cardiovascular disease (CVD) risk is U-shaped with a protective effect of moderate alcohol consumption. The relation of alcohol consumption level with AIx has not been widely investigated, which prompted this study of the relation of alcohol consumption with AIx in a population-based cohort of men aged 40–80 years.
Methods Three hundred and seventy-four men (mean age 60·5 years) participated in this cross-sectional study. Alcohol consumption and smoking habits were determined through a validated questionnaire. Fasting blood samples were drawn and analyzed for glucose and lipid levels and AIx was estimated by radial applanation tonometry using the SphygmoCor Device. The resultant data were analyzed using linear regression models.
Results Age, height, heart rate, blood pressure, packyears, current smoking, presence of CVD and hypertension were independently related to AIx. The relation of alcohol consumption with AIx was U-shaped, with a significantly lower AIx in the group drinking 4–8 glasses/week (difference = −2·91%, 95% CI [−5·65; −0·18]) relative to those drinking 0–3 glasses/week. Additional adjustment for current smoking did not change this relationship, but adjustment for pulse wave velocity attenuated the relation.
Conclusions In a population-based cohort of men aged 40–80 years the relation of alcohol consumption level with AIx was U-shaped, further expanding the evidence for vascular protective effects of moderate alcohol intake.