Department of Life Sciences, National Chung Hsing University (C. C. Yen, S. H. Yang, C. Y. Lin, C. M. Chen); Department of Internal Medicine, China Medical University Hospital (C. C. Yen), Taichung, Taiwan.
Stem cells in the lung parenchyma and prospects for lung injury therapy
Article first published online: 18 APR 2006
European Journal of Clinical Investigation
Volume 36, Issue 5, pages 310–319, May 2006
How to Cite
Yen, C. C., Yang, S. H., Lin, C. Y. and Chen, C. M. (2006), Stem cells in the lung parenchyma and prospects for lung injury therapy. European Journal of Clinical Investigation, 36: 310–319. doi: 10.1111/j.1365-2362.2006.01638.x
- Issue published online: 18 APR 2006
- Article first published online: 18 APR 2006
- Received 30 August 2005; accepted 6 March 2006
- Acute lung injury;
- alveolar type 1 cells;
- alveolar type 2 cells;
- lung parenchyma;
- lung repair;
- stem cell.
Until recently, it was thought that only embryonic stem cells were pluripotent and that adult stem cells were restricted in their differentiative and regenerative potential to become the tissues in which they reside. However, the discovery that adult stem cells in one tissue can contribute to the formation of other tissues, especially after injury or cell damage, implies that stem cells have developmental plasticity. For example, haematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) from bone marrow can be used to regenerate diverse tissues at distant sites, including the lung. This article reviews the character of stem cells in the lung parenchyma and focuses on the potential uses of adult stem cells in research of lung injury and lung disease therapies.