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Effect of bariatric surgery on circulating chemerin levels

  1. C. Ress1,
  2. A. Tschoner1,
  3. J. Engl1,
  4. A. Klaus2,
  5. H. Tilg3,
  6. C. F. Ebenbichler1,
  7. J. R. Patsch1,
  8. S. Kaser1

Article first published online: 25 JAN 2010

DOI: 10.1111/j.1365-2362.2010.02255.x

Issue

European Journal of Clinical Investigation

European Journal of Clinical Investigation

Volume 40, Issue 3, pages 277–280, March 2010

Additional Information

How to Cite

Ress, C., Tschoner, A., Engl, J., Klaus, A., Tilg, H., Ebenbichler, C. F., Patsch, J. R. and Kaser, S. (2010), Effect of bariatric surgery on circulating chemerin levels. European Journal of Clinical Investigation, 40: 277–280. doi: 10.1111/j.1365-2362.2010.02255.x

Author Information

  1. 1

    Department of Medicine I

  2. 2

    Department of Surgery

  3. 3

    Christian Doppler Research Laboratory for Gut Inflammation, Department of Medicine II, Medical University Innsbruck, Innsbruck, Austria

*Susanne Kaser, MD, Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Tel.: +43 512 504 0; fax: + 43 512 504 28539; e-mail: susanne.kaser@i-med.ac.at

Publication History

  1. Issue published online: 26 FEB 2010
  2. Article first published online: 25 JAN 2010
  3. Received 15 November 2009; accepted 28 December 2009

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Keywords:

  • Bariatric surgery;
  • chemerin;
  • obesity;
  • weight loss

Eur J Clin Invest 2010; 40 (3): 277–280

Abstract

Background  Subclinical inflammation in obesity is critical for development of several obesity-associated disorders. We set out to investigate the effect of pronounced weight loss on circulating chemerin levels, a chemoattractant protein that also influences adipose cell function by paracrine and autocrine mechanisms.

Material and methods  Thirty-two obese patients undergoing bariatric surgery were tested before and on an average of 18 months after gastric banding or gastric bypass surgery.

Results  Pronounced weight loss after bariatric surgery was accompanied by improvements in parameters of lipid and glucose metabolism and increased adiponectin levels. Chemoattractant chemerin significantly decreased from 175·91 ± 24·50 to 145·53 ± 26·44 ng mL−1 after bariatric surgery (P ≤ 0·01). Concomitantly, hs-CRP as a marker of subclinical inflammation was significantly reduced after weight reduction (P ≤ 0·01).

Conclusions  We hypothesize that weight-loss induced reduction in circulating chemerin might in conjunction with other factors be associated with diminished recruitment of macrophages in adipose tissue and reduction of subclinical inflammation, which again could partly explain beneficial long-term effects of weight reduction in obese subjects.

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