The value of copper and zinc levels in hernia formation
Article first published online: 18 OCT 2010
© 2010 The Authors. European Journal of Clinical Investigation © 2010 Stichting European Society for Clinical Investigation Journal Foundation
European Journal of Clinical Investigation
Volume 41, Issue 3, pages 285–290, March 2011
How to Cite
Ozdemir, S., Ozis, E. S., Gulpinar, K., Aydın, S. M., Eren, A. A., Demirtas, S. and Korkmaz, A. (2011), The value of copper and zinc levels in hernia formation. European Journal of Clinical Investigation, 41: 285–290. doi: 10.1111/j.1365-2362.2010.02406.x
- Issue published online: 8 FEB 2011
- Article first published online: 18 OCT 2010
- Received 19 April 2010; accepted 16 September 2010
- fascia transversalis;
Eur J Clin Invest 2011; 41 (3): 285–290
Background A defect in collagen metabolism is suspected to be one of the factors responsible for hernia formation. Lysyl oxidase is a copper-dependent enzyme in the process that provides for the structural integrity of collagen molecules, while zinc is essential for tissue maintenance.
Materials and methods In a prospective fashion, copper and zinc levels were measured in plasma and tissue specimens obtained from indirect (n = 23), direct (n = 20) and incisional hernia patients (n = 19) and from healthy controls (laparoscopic cholecystectomy patients, n = 15) by enzymatic colorimetric analysis.
Results Groups were similar in age, comorbid diseases and body mass index. Whereas plasma levels of Cu and Zn in hernia and control patients were similar, and tissue levels were significantly lower in all hernia groups (especially the incisional hernia group) compared to controls (P < 0·001). The incisional hernia group had significantly lower tissue copper levels than direct hernia patients and lower zinc levels than indirect hernia patients.
Conclusions Patients with all types of hernia, especially those with incisional hernias, have significantly lower tissue copper and zinc levels than control patients, despite having similar plasma levels. This finding might reflect excessive consumption or dysfunction of lysyl oxidase as playing a role in the aetiology of hernias.