Association of serum lipids with arterial stiffness in a population-based study in Beijing
Article first published online: 14 FEB 2011
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation
European Journal of Clinical Investigation
Volume 41, Issue 9, pages 929–936, September 2011
How to Cite
Wang, F., Ye, P., Luo, L., Xiao, W., Qi, L., Bian, S., Wu, H., Sheng, L., Xiao, T. and Xu, R. (2011), Association of serum lipids with arterial stiffness in a population-based study in Beijing. European Journal of Clinical Investigation, 41: 929–936. doi: 10.1111/j.1365-2362.2011.02481.x
- Issue published online: 3 AUG 2011
- Article first published online: 14 FEB 2011
- Received 7 August 2010; accepted 5 January 2011
- Arterial stiffness;
- population-based study;
- pulse wave velocity;
- serum lipids
Eur J Clin Invest 2011; 41 (9): 929–936
Background Some cardiovascular risk factors such as age, hypertension and diabetes have been confirmed to be positively correlated with arterial stiffness. However, the relationship between serum lipids and arterial stiffness is incompletely understood. Recent studies have been far from conclusive and consistent data were not obtained. We investigated the relationship between serum lipids and pulse wave velocity (PWV) in community-dwelling individuals in Beijing, China.
Methods This was a population-based, cross-sectional sample of adults (n = 2375; 48·1% men; age range, 40–96 years) from two communities in Beijing. A questionnaire was used for the risk factors of arterial stiffness. Anthropometry, blood pressure and heart rate were measured. Values of fasting plasma glucose (FPG), serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and uric acid were measured. Carotid–femoral PWV (cfPWV) and carotid–radial PWV (crPWV) were assessed non-invasively.
Results Carotid–femoral pulse wave velocity was significantly positively related to TC (r = 0·221; P < 0·0001), LDL-C (r = 0·193; P < 0·0001) and inversely related to HDL-C (r = −0·240; P < 0·0001), but not with TG (r = 0·073; P = 0·6721). crPWV was inversely related to HDL-C (r = −0·272; P < 0·0001), but not with TC (r = 0·007; P = 0·4781), LDL-C (r = 0·021; P = 0·6393) or TG (r = 0·008; P = 0·2498). The multiple regression analysis showed that LDL-C was independently associated with cfPWV and that HDL-C was inversely associated with cfPWV and crPWV. TC and TG were not independently related to cfPWV and crPWV.
Conclusions These data show the correlation between some of the parameters of serum lipids and arterial stiffness. LDL-C was independently associated with aortic stiffness, and HDL-C was independently inversely associated with aortic stiffness and peripheral stiffness.