Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration


  • This article is being simultaneously published in 2011 in European Journal of Epidemiology, European Journal of Clinical Investigation, Journal of Clinical Epidemiology and European Journal of Human Genetics. Reproduced by permission of the authors.

A. C. J. W. Janssens, Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands. Tel.: +31 10 7044214; fax: +31 10 7044657; e-mail:


Eur J Clin Invest 2011; 41 (9): 1010–1035

Summary Points

  •  The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice.
  •  The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality.
  •  Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction.
  •  A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines.
  •  These recommendations aim to enhance the transparency, quality and completeness of study reporting and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis.