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Table S1. Search terms used for detecting original research articles that evaluated the diagnostic accuracy of detecting K-ras mutation for diagnosis of EPC.

Table S2. Stated objectives of 30 articles evaluating the utility of assessing the K-ras mutational status for the diagnosis of exocrine pancreatic cancer in at least 50 patients.

Table S3. Conclusions of 30 articles regarding the clinical application of detecting K-ras mutations in the diagnosis of exocrine pancreatic cancer in at least 50 patients.

Table S4. Data extracted from 34 patient series evaluating the utility of detecting K-ras mutations in the diagnosis of exocrine pancreatic cancer in at least 50 patients.

Table S5. Summary of the analytical test characteristics in 30 articles evaluating K-ras mutations for the diagnosis of exocrine pancreatic cancer in at least 50 patients

Table S6. Quality analysis of 34 patient series evaluating the utility of detecting K-ras mutations in the diagnosis of exocrine pancreatic cancer in at least 50 patients

Table S7. Diagnostic sensitivity of K-ras mutations in exocrine pancreatic cancer according to cancer stage

Table S8. Sensitivity and specificity of detecting K-ras mutations in combination with tumour marker CA19·9 in 3 studies with available data.

Table S9. Sensitivity and specificity of detecting K-ras mutations in combination with other genetic markers.

Table S10. Sensitivity and specificity of detecting K-ras mutations in combination with other diagnostics procedures.

Annex. References of 30 articles (34 studies) evaluating the utility of assessing the K-ras mutational status for the diagnosis of exocrine pancreatic cancer in at least 50 patients.

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ECI_2495_sm_TableS1-S10.doc316KSupporting info item
ECI_2495_sm_Annex.doc64KSupporting info item

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