Visceral obesity and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy men
Article first published online: 7 MAR 2011
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation
European Journal of Clinical Investigation
Volume 41, Issue 9, pages 987–994, September 2011
How to Cite
Alokail, M. S., Al-Daghri, N. M., Al-Attas, O. S., Alkharfy, K. M., Sabico, S. B. and Ullrich, A. (2011), Visceral obesity and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy men. European Journal of Clinical Investigation, 41: 987–994. doi: 10.1111/j.1365-2362.2011.02496.x
- Issue published online: 3 AUG 2011
- Article first published online: 7 MAR 2011
- Received 15 September 2010; accepted 25 January 2011
- insulin resistance;
- prostate disease;
- waist–hip ratio
Eur J Clin Invest 2011; 41 (9): 987–994
Background Prostate disease incidence is expected to rise among developing nations secondary to increased prevalence of obesity and the elderly. Although many case–control studies have associated obesity to prostate cancer aggressiveness, few have correlated markers of prostate pathology to biomarkers of visceral obesity and insulin resistance, using an apparently healthy cohort. This study aims to fill this gap.
Materials and methods The 219 consenting adult Arab men, aged 30–70 years, were included in this cross-sectional study. Demographics were noted and anthropometrics measured. Fasting blood samples were extracted, and glycaemic and lipid profile were determined using routine laboratory methods. Serum adipocytokines and inflammatory markers were measured using multiplex assays. Total prostate-specific antigen (tPSA), free PSA (fPSA), parathyroid-related protein (PTHrP) and endoglin were measured using enzyme-linked immunosorbent assays.
Results Serum triglycerides and waist–hip ratio (WHR) were significantly and positively associated with circulating (tPSA) levels in all subjects (P < 0·01). Systolic blood pressure (SBP), adiponectin, active plasminogen activator inhibitor-1 (aPAI-1) and insulin-like growth factor-1 (IGF-1) had significant inverse associations to tPSA. Stepwise linear regression revealed that adiponectin, IGF-1, WHR and PTHrP explained 30% of variance in tPSA levels (P < 0·0001), while SBP, resistin and BMI explained 18·7% of variance in endoglin (P = 0·001).
Conclusions The associations of adiponectin and WHR strengthen the link between insulin resistance and visceral adiposity to prostate volume markers among apparently healthy Arab men. Follow-up studies are needed to extend these preliminary findings so that early interventions can be provided to those at increased risk.