Association between kidney and cardiac diastolic function in Chinese subjects without overt disease: correlation with ageing and inflammatory markers


Xiao-Juan Bai, Department of Gerontology and Geriatrics, The First affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China. Tel.: +86 24 83282770; fax: +86 24 83282693; e-mail:


Eur J Clin Invest 2011; 41 (10): 1077–1086


Background  Age-related changes in kidney structure and function have been well documented. This study aimed to assess the relationship between declines of normal ageing-related kidney function and cardiac diastolic function in a healthy Chinese population.

Materials and methods  A total of 852 healthy adults aged 30–98 years were enrolled and divided into four groups according to quartiles of estimated glomerular filtration rate (eGFR) and cystatin C (CYSC). Cardiac diastolic function was measured by ratio of peak velocity of early filling to peak velocity of atrial filling (E/A), which was derived by B-mode echocardiography. Lower E/A was defined as measures under the 25th percentile of sample distribution (0·784).

Results  Age was significantly associated with eGFR (= −0·102, P < 0·01), CYSC (r = 0·544, P < 0·01) and E/A (= −0·381, < 0·01). Binary logistic regression analysis revealed that second, third and fourth quartile groups of CYSC and fourth quartile of eGFR were significantly associated with lower E/A in an unadjusted model. However, these associations were lost after full adjustment.

Conclusions  Our results confirm that ageing is a major factor contributing to declines in both kidney and cardiac diastolic function in a healthy population. Adjustment for covariates, however, showed that normal ageing-related declines in kidney function and cardiac diastolic function are not independently linked.