Small artery dilation and endothelial markers in cardiovascular risk patients
Article first published online: 1 JUN 2011
© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation
European Journal of Clinical Investigation
Volume 42, Issue 1, pages 34–41, January 2012
How to Cite
Aragonès, G., Ferré, R., Girona, J., Plana, N., Merino, J., Heras, M. and Masana, L. (2012), Small artery dilation and endothelial markers in cardiovascular risk patients. European Journal of Clinical Investigation, 42: 34–41. doi: 10.1111/j.1365-2362.2011.02553.x
- Issue published online: 7 DEC 2011
- Article first published online: 1 JUN 2011
- Received 9 December 2010; accepted 11 May 2011
- Cardiovascular risk;
- endothelial function;
- peripheral artery tonometry;
- reactive hyperaemia index;
- small arteries
Eur J Clin Invest 2012; 42 (1): 34–41
Background The use of methods based on reactive hyperaemia of small distal arteries to assess endothelial function (EF) is increasing; however, the mechanisms regulating vascular function in large and small arteries are probably different. We studied the correlations between the hyperaemia reactivity of small peripheral arteries determined by peripheral artery tonometry (PAT) and the levels of serum biomarkers of EF, inflammation and oxidation in patients with cardiovascular (CV) risk factors.
Methods Four hundred and seven patients with intermediate CV risk were recruited into a cross-sectional study to examine whether soluble endothelial, inflammatory and lipid oxidative biomarkers correlate with small artery reactive hyperaemia index (saRHI) values, which were measured by PAT.
Results A significant correlation was found between saRHI values and the concentrations of soluble E-selectin (sE-selectin) and soluble vascular cell adhesion molecule 1 (sVCAM-1). These correlations were stronger when only non-metabolic syndrome patients (46%) were analysed (r = −0·310, P < 0·0001; r = −0·264, P < 0·0001, respectively). In this subgroup, the oxidised low-density lipoprotein/LDL (oxLDL/LDL) was also correlated with saRHI (r = −0·193, P = 0·009). A stepwise regression study showed that sE-selectin was the only biomarker significantly correlated with saRHI values (P < 0·0001). In multivariate linear regression analysis, this relationship was still strong when the main confounding covariates were taken into consideration.
Conclusions Elevated levels of sE-selectin and, to a smaller degree, sVCAM-1 and oxLDL/LDL are associated with lower postischemic reactivity in the small distal arteries. sE-selectin is the main determinant biomarker of saRHI as assessed by regression analysis. The presence of multiple risk factors weakens this association.