STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement



This article is corrected by:

  1. Errata: Corrigendum Volume 42, Issue 4, 462, Article first published online: 14 March 2012

  • This article is being simultaneously published in 2011 in PLoS Medicine, Journal of Clinical Epidemiology, Preventive Medicine, Mutagenesis, Journal of Epidemiology and Community Health, European Journal of Epidemiology and European Journal of Clinical Investigation. Reproduced by permission of the authors.

Dr Valentina Gallo, Research Associate, School of Public Health, Imperial College London, St Mary’s Campus, Norfolk place, W2 1PG London, UK. Tel.: +44/(0) 20/7594 3463; fax: +44/(0) 20/7594 0768; e-mail:


Eur J Clin Invest 2012; 42 (1): 1–16

Summary points

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating interactions between external and/or endogenous agents and body components or processes. The need for improved reporting of scientific research led to influential statements of recommendations such as the STrengthening Reporting of OBservational studies in Epidemiology (STROBE) statement. The STROBE initiative established in 2004 aimed to provide guidance on how to report observational research. Its guidelines provide a user-friendly checklist of 22 items to be reported in epidemiological studies, with items specific to the three main study designs: cohort studies, case–control studies and cross-sectional studies. The present STrengthening the Reporting of OBservational studies in Epidemiology –Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE statement implementing nine existing items of STROBE and providing 17 additional items to the 22 items of STROBE checklist. The additions relate to the use of biomarkers in epidemiological studies, concerning collection, handling and storage of biological samples; laboratory methods, validity and reliability of biomarkers; specificities of study design; and ethical considerations. The STROBE-ME recommendations are intended to complement the STROBE recommendations.